Use of Galangal fruit and its extract in pharmacy

Abstract

An application of galanga galangal fruit and its extract in preparing 5 alpha-reductase inhibitor and the medicines for treating prostatoplasia with high curative effect is disclosed.

Description

technical field [0001] The invention relates to a new application of the traditional Chinese medicine red cardamom, specifically, the application in the preparation of 5α-reductase inhibitors and drugs for treating benign prostatic hyperplasia, and belongs to the field of traditional Chinese medicines. Background technique [0002] BPH (benign prostatic hyperplasia, BPH) is prostate hypertrophy, which is a common disease that seriously affects elderly men. It is characterized by static obstruction caused by benign prostatic hyperplasia and dynamic obstruction caused by increased prostate smooth muscle tension. Manifested as bladder urine outflow obstruction, urgency, frequency, and residual urine, often leading to urinary tract infection and even induced nephritis. Although BPH itself is not a life-threatening disease in the near future, it obviously affects the physical activity and social ability of patients, thereby affecting their quality of life and causing great pain t...

AI Technical Summary

Problems solved by technology

Finasteride is currently a 5α-reductase inhibitor widely used clinically. It has high safety and is well tolerated by patients. However, there are still some adverse reactions, mainly caused by the decrease of DHT level, including impotence or ejaculation. Failure, loss of libido, feminized breasts, and related symptoms

[0004] Cardamom is the fruit of Alpinia galanga Willd., a plant of the Zingiberaceae family. It is mainly produced in Guangdong, Guangxi, Yunnan and other places. It is pungent and warm, and it belongs to the spleen and stomach meridian. Cold pain, food accumulation, vomiting and diarrhea, etc. ("Clinical Chinese Materia Medica", edited by Zhang Tingmo, China Press of Traditional Chinese Medicine, 2004, 8). Modern pharmacological research shows that: the components isolated from the methanol extract of red cardamom seeds Intraperitoneal injection can significantly inhibit rat ulcers; the volatile oil of its rhizomes shows antimicrobial activity, can resist Gram-positive bacteria, yeast and some skin fungi, and has cytotoxicity and antifungal activity; The ingredients have anti-tumor effects (Volume VIII of "Chinese Materia Medica", Shanghai Science and Technology Press, 1999). But so far, there have been no reports that cardamom inhibits 5α-reductase, prevents or treats benign prostatic hyperplasia and related diseases.

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