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Method for preparing raw material of pleuromutilin for use in tiamulin synthesizing process

A technology of pleuromutilin and synthesis process, which is applied in the direction of organic chemistry, can solve the problems of complex process and low yield, and achieve the effect of simple process, high yield and easy operation

Active Publication Date: 2006-05-24
江苏赛奥生化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] At present, the raw material of pleuromutilin used in the synthesis of tiamulin is obtained by extracting pleuromutilin from the fermentation broth, centrifuging to obtain pleuromutilin, and then re-adding the solvent. The process is complex and the yield is high. Low

Method used

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Embodiment Construction

[0010] A method for preparing a pleuromutilin raw material used in the synthesis of tiamulin is characterized in that it comprises the following steps:

[0011] Dry the wet cells containing pleuromutilin to obtain dry cells, then use methyl ethyl butyl ketone as a solvent to extract at room temperature, filter the obtained extract, discard the filter residue, and concentrate the filtrate to obtain pleuromutilin Concentrate. When drying the wet bacteria, use a flash dryer, the inlet air temperature is 120-130°C, and the outlet air temperature is 70-80°C. When concentrating the filtrate, the temperature is 70-80°C, and the vacuum degree is -0.05-0.07MPa.

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Abstract

The invention discloses a method for preparing Pleuromutilin raw material used in the course of synthesizing Thiamutin, comprising the steps: drying the wet thalli containing the Pleuromutilin to obtain dry thalli, then making extraction at normal temperature by using methyl ethyl butyl ketone as menstruum, filtering the extracted liquid, discarding filter residues, concentrating the filtrate and obtaining Pleuromutilin concentrate. The invention has high Thiamutin yield, is easy to operate and only uses a kind of menstruum.

Description

Technical field: [0001] The invention relates to a preparation method of pleuromutilin used for synthesizing tiamulin. Background technique: [0002] At present, the raw material of pleuromutilin used in the synthesis of tiamulin is obtained by extracting pleuromutilin from the fermentation broth, centrifuging to obtain pleuromutilin, and then re-adding the solvent. The process is complex and the yield is high. Low. Invention content: [0003] The object of the present invention is to provide a method for preparing pleuromutilin raw materials used in the synthesis process of tiamulin with simple process, high yield and easy operation. [0004] Technical solution of the present invention is: [0005] A method for preparing a pleuromutilin raw material used in the synthesis of tiamulin is characterized in that it comprises the following steps: [0006] Dry the wet cells containing pleuromutilin to obtain dry cells, then use methyl ethyl butyl ketone as a solvent to extrac...

Claims

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Application Information

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IPC IPC(8): C07D211/54C07D211/56
Inventor 韩勤更沈敏祥杨剑峰
Owner 江苏赛奥生化有限公司
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