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Use of CETP inhibitors and optionally HMG COA reductable inhibitors and/or antihypertensive agents

A drug, selected technology, applied in the field of elaide

Inactive Publication Date: 2005-09-07
PFIZER PRODS ETAT DE CONNECTICUT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although elevated LDL-C is probably the most recognized form of dyslipidemia, it is not only a host of lipid-related factors that can lead to CHD

Method used

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  • Use of CETP inhibitors and optionally HMG COA reductable inhibitors and/or antihypertensive agents
  • Use of CETP inhibitors and optionally HMG COA reductable inhibitors and/or antihypertensive agents
  • Use of CETP inhibitors and optionally HMG COA reductable inhibitors and/or antihypertensive agents

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Embodiment Construction

[0187] The present invention is not limited to any specific structure or type of CETP inhibitor. In contrast, the present invention has general suitability for a class of CETP inhibitors. The compounds that are the subject of the present invention can be found in many patents and published applications, including: DE19741400A1; DE19741399A1; WO9914215A1; WO9914174; DE19709125A1; DE19704244A1; DE19704243A1; EP818448A1; WO9804528A2; WO9941237A1; WO9914204A1; WO9835937A1; JP11049743; WO200018721; WO200018723; WO200018724; WO200017164; WO200017165; WO200017166; EP992496; and EP987251, the entire contents of these documents are incorporated herein by reference for all purposes.

[0188] A class of CETP inhibitors used in the present invention are 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines substituted with oxygen having the general formula I and the compounds are pharmaceutically acceptable The salt, enantiomer or stereoisomer composition of:

[0189]

[0190] ...

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PUM

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Abstract

The present invention relates to cholesteryl ester transfer protein (CETP) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors optionally in combination with certain therapeutic agents, such as antihypertensive agents, in the treatment of certain diseases / disorders Applications.

Description

[0001] The present invention relates to cholesteryl ester transfer protein (CETP) inhibitors, pharmaceutical compositions containing such inhibitors, and such inhibitors optionally combined with certain therapeutic agents, such as antihypertensive drugs, in the treatment of certain diseases / diseases Applications. Background of the invention [0002] Atherosclerosis and its associated coronary artery disease (CAD) is the leading cause of death in the industrialized world. Despite attempts to change secondary risk factors (smoking, obesity, lack of exercise) and treat lipemia through dietary changes and drug therapy, coronary heart disease (CHD) is still the most common cause of death in the United States, of which cardiovascular diseases account for all 44% of deaths, and 53% of them are related to atherosclerotic coronary heart disease. [0003] It has been confirmed that the risk of this disease is closely related to certain plasma lipid levels. Although elevated LDL-C may be the ...

Claims

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Application Information

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IPC IPC(8): C07D215/42A61K31/00A61K31/22A61K31/343A61K31/366A61K31/40A61K31/4015A61K31/404A61K31/4418A61K31/4422A61K31/47A61K31/4706A61K31/505A61K45/00A61K45/06A61P1/04A61P1/16A61P3/04A61P3/06A61P3/10A61P3/14A61P7/02A61P9/00A61P9/06A61P9/10A61P9/12A61P9/14A61P11/00A61P13/02A61P13/12A61P15/00A61P17/02A61P19/02A61P25/00A61P25/02A61P25/08A61P25/28A61P27/02A61P29/00A61P33/12A61P35/00A61P37/02A61P37/06A61P39/06A61P43/00
CPCA61K45/06A61K31/00A61K31/4706A61P1/04A61P1/16A61P11/00A61P13/02A61P13/12A61P15/00A61P17/02A61P19/02A61P25/00A61P25/02A61P25/08A61P25/28A61P27/02A61P29/00A61P3/14A61P33/12A61P35/00A61P3/04A61P3/06A61P37/02A61P37/06A61P39/06A61P43/00A61P7/02A61P9/00A61P9/06A61P9/10A61P9/12A61P9/14A61P3/10Y02A50/30A61K2300/00A61K31/435A61K31/47
Inventor 图·T·古延查尔斯·L·希尔詹姆斯·H·雷夫金罗杰·B·鲁格里
Owner PFIZER PRODS ETAT DE CONNECTICUT
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