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Process for rapid preparation of high pure pharmaceutical matters from patrinia villosa juss

A high-purity technology, applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of time-consuming and laborious, polluting the environment, irreversible adsorption, etc., and achieves overcoming cumbersome operations and separation High efficiency and large preparation effect

Inactive Publication Date: 2006-12-13
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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AI Technical Summary

Problems solved by technology

[0009] Traditional separation and preparation methods such as column chromatography and recrystallization are used to separate effective monomers in plants, which is time-consuming and laborious and pollutes the environment [C.L Ky, M.Noirot, S.Hamon, J.Agric.Food.Chem.1997, 45: 786; W.M.Yan, Acta Botanica Sinica, 1979, 20:54; J.J Liu, G.L.Zhao, H.Wang, X.H.Zhang, J.Cent.South.Univ.T.2002, 9:246], and the fixed relative samples used There are deficiencies such as irreversible adsorption

Method used

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  • Process for rapid preparation of high pure pharmaceutical matters from patrinia villosa juss
  • Process for rapid preparation of high pure pharmaceutical matters from patrinia villosa juss
  • Process for rapid preparation of high pure pharmaceutical matters from patrinia villosa juss

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Embodiment 1

[0030] 1. Weigh 6.0kg of the crude powder of Patrinia officinalis, extract twice with 10 times the amount of 40% ethanol under reflux, each time for 1.5h, filter, add 8 times the amount of 95% ethanol to the filter residue and extract under reflux twice, each time After 1.5 hours, filter, combine the filtrates, and concentrate under reduced pressure to extract about 2000ml.

[0031] 2. Take the concentrated extract, add 1000ml of water to suspend it, place it in a 5000ml separatory funnel, add 1000ml of petroleum ether and shake fully, then separate the layers, separate the petroleum ether layer, extract three times in this way, and combine petroleum ether for extraction liquid. Then add 1000ml of n-butanol to the water layer, shake well and then separate the layers, separate the n-butanol layer, extract three times like this, and combine the n-butanol extracts. The extract was concentrated under reduced pressure (concentration temperature: 60°C) and dried under reduced press...

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Abstract

The invention provides a rapid preparation method of some high pure pharmaceutical matter of patrinia villosa juss. The process comprises : (1) extraction of medical materials; (2) preparation of crude extract; (3) separation and purification of obtained crude extract by high-speed countercurrent chromatography, comprising solvent system for stationary phase and mobile phase, filling stationary phase in countercurrent chromatographic column, running the column, pumping the mobile phase into column, injecting sample via injection valve, and receiving the demanded components according to the detection spectrogram, wherein, the said two phase solvent system is composed of n-hexane, ethyl acetate, methanol, water and ethyl acetate, n-butyl alcohol, water.

Description

technical field [0001] The invention relates to a method for separating and purifying active ingredients of traditional Chinese medicine, more specifically, the invention relates to a high-purity golden amido alcohol ester, isoorientin and isovitexin rapid separation and preparation method of high-speed countercurrent chromatography in Patrinia diffusa. Background technique [0002] Patrinia Villosa Juss (Patrinia Villosa Juss), also known as Kucai, Kuzhai, and Luchang, is a perennial herb of Patriniaceae, distributed in East China, Central China, South China and Southwest China. Because it contains a variety of amino acids, vitamins, minerals and other beneficial ingredients, it is widely consumed by people. It is also a commonly used traditional Chinese medicine. It has the effects of clearing heat and dampness, detoxifying and discharging pus, promoting blood circulation and removing blood stasis, clearing heart and calming nerves, promoting liver cell regeneration, impro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C237/22C07C231/22C07H17/07C07H1/08
Inventor 范国荣彭金咏洪战英柴逸峰吴玉田汪学昭
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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