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Fast disclosing solution for lymph node examination and usage thereof

A lymph node and rapid technology, applied in the field of lymph node examination of malignant tumor specimens, can solve the problems of time-consuming, expensive, and easy to miss the metastatic lymph nodes, and achieve the effect of easy operation and easy selection.

Inactive Publication Date: 2005-11-09
CENT SOUTH UNIV
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Problems solved by technology

[0004] 1. The manual method commonly used in clinical practice is to find and pick lymph nodes on specimens by visual inspection and hand touch, which is simple and easy to implement, but it is easy to miss metastatic lymph nodes with a diameter of less than 5 mm, and these missed metastatic lymph nodes account for 50% of all metastatic lymph nodes. %, so it may cause inaccurate diagnosis and treatment of patients
[0005] 2. The transparent method (also known as the cleaning method) commonly used in the laboratory is to dissolve and remove the fat on the specimen with chemical drugs, and can thoroughly check the lymph nodes of the specimen, so that the patient can receive accurate diagnosis and treatment, but this method is time-consuming (about 10 hours). days) laborious and expensive

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  • Fast disclosing solution for lymph node examination and usage thereof

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Embodiment Construction

[0037] 1. Materials and Methods

[0038] 1.1 Materials From June to December 2001, there were 20 specimens collected from the Department of General Surgery of the Third Xiangya Hospital of Central South University after radical resection of colorectal cancer, including 11 males and 9 females. Age ranged from 38 to 68 years, with an average of 55.35 years; 13 cases of colon cancer and 7 cases of rectal cancer; all colorectal cancers underwent complete surgical resection of the primary tumor and other mesentery.

[0039] The composition of quick display liquid is by volume percentage: 95% absolute alcohol 55%, ether 20%, turpentine 10%, glacial acetic acid 5%, buffered formalin 10%, sodium dihydrogen phosphate 5g, methylene blue powder 2g and mix well , prepare 1000ml, and put it in a well-sealed container for later use.

[0040] 1.2 Methods Using the self-control method, each specimen was processed separately by the traditional method and the rapid display liquid method.

[0...

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Abstract

The composition (percentage by volume) of the quick display liquid of the present invention is: anhydrous alcohol, ether, turpentine, sodium dihydrogen phosphate, a small amount of methylene blue, etc.; The malignant tumor specimen is placed in a container filled with lymph node examination rapid display liquid and sealed, soaked for 6 to 12 hours; the amount of display liquid is 3 times the volume of the sample; the present invention not only significantly increases the number of normal and metastatic lymph nodes detected, Moreover, the transfer rate (that is, the percentage of transferred cases to the total number of cases) can be made more accurate. The display speed is fast, time-saving, cheap, and the inspection result is accurate.

Description

technical field [0001] The invention relates to lymph node inspection of malignant tumor specimens, especially a liquid for inspection. [0002] Clinically, all lymph nodes must be detected in the resection specimens of malignant tumors, so as to further check whether there is lymphatic metastasis and the degree of metastasis, so as to guide diagnosis, treatment and prognosis. Taking colorectal cancer as an example, the international standard for the minimum number of lymph nodes to be removed per specimen is 8-16. Background technique [0003] The current methods for lymph node examination of resected specimens of malignant tumors include: [0004] 1. The manual method commonly used in clinical practice is to find and pick lymph nodes on specimens by visual inspection and hand touch, which is simple and easy to implement, but it is easy to miss metastatic lymph nodes with a diameter of less than 5 mm, and these missed metastatic lymph nodes account for 50% of all metastati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/483G01N33/50G01N33/574
Inventor 陈道瑾向开敏
Owner CENT SOUTH UNIV
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