Ibuprofen sugar conjugated product and its preparation method and application

A technology of glycoconjugates and glucosamine, applied in the field of ibuprofen glycoconjugates and its preparation and application, can solve the problems of low bioavailability, strong gastrointestinal side effects, short half-life of drugs, etc., and achieve simplified operation steps Effect

Inactive Publication Date: 2005-11-09
OCEAN UNIV OF CHINA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Ibuprofen is a non-steroidal anti-inflammatory drug (NSAIDs), which is an effective drug for the treatment of rheumatism and rheumatoid arthritis, but it has strong side effects on the gastrointestinal tract, and the drug has a short half-life and low bioavailability
In order to solve these problems, people have carried out many researches, such as the improvement of dosage forms, the research of specific non-steroidal anti-inflammatory drugs-COX2 inhibitors and the research of NO-NSAIDs, etc., but none of them can completely solve the above problems

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ibuprofen sugar conjugated product and its preparation method and application
  • Ibuprofen sugar conjugated product and its preparation method and application
  • Ibuprofen sugar conjugated product and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] 1. Dissolve N-acetylglucose in a saturated ammonium bicarbonate aqueous solution at a ratio of 1% (w / v), stir and react at 40-45°C for 2-3 days, and add solid ammonium bicarbonate in portions during the reaction In order to maintain the saturated state of the solution, after the reaction is completed, add a certain amount of distilled water to dilute, then concentrate to half under reduced pressure, then add water to the original volume, and then concentrate to half, repeat this operation 5 times, and finally freeze-dry to obtain N - Crude acetylglucosamine.

[0010] 2. Dissolve 1.22g (5.5mmol) of crude N-acetylglucosamine in 30mL of methanol, add 1.0g (7.1mmol) of triethylamine, and add 1.5g (6.8mmol) of 2 -(isobutylphenyl)-isopropionyl chloride, continue to react under these conditions for 1.5h, add an appropriate amount of water to precipitate a large amount of solid after stopping the reaction, filter, and recrystallize the obtained filter residue in ethanol to obta...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A brufen saccharide conjugate C21H32N2O6 or 1-(2-deoxy-2-N-acetyl-glucose amine)-(+ / -) brufen is prepared through converting N-acetylglocose in the supersaturated aqueous solution of ammonium dicarbonate to become N-acetylglucose amine, and coupling it with 2-(isobutylphenyl)-isopropylacylchlorine. It can be used to prepare the medicine for treating rheumatic or rheumatoid arthritis.

Description

technical field [0001] The invention relates to an ibuprofen glycoconjugate and its simple and effective preparation method and application. Background technique [0002] Ibuprofen is a non-steroidal anti-inflammatory drug (NSAIDs), which is an effective drug for treating rheumatism and rheumatoid arthritis, but it has strong side effects on the gastrointestinal tract, and the drug has a short half-life and low bioavailability. In order to solve these problems, people have carried out many researches, such as the improvement of dosage forms, the research of specific non-steroidal anti-inflammatory drugs-COX2 inhibitors and the research of NO-NSAIDs, etc., but none of them can completely solve the above problems. Contents of the invention [0003] The object of the present invention is to provide a kind of ibuprofen glycoconjugate and its preparation method and application, it can overcome the above-mentioned shortcoming of prior art. [0004] A kind of ibuprofen sugar con...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7028A61P19/02A61P29/00C07H15/12
Inventor 宋妮李英霞李春霞褚世栋
Owner OCEAN UNIV OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap