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Systems and methods for selecting bacteriophage therapy based on time and location

A phage and phage technology, applied in biochemical equipment and methods, epidemic warning systems, medical data mining, etc., can solve problems such as increasing time

Pending Publication Date: 2022-08-05
ADAPTIVE PHAGE THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This manual check must be performed for each host-phage combination (i.e., each well), further adding to the time

Method used

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  • Systems and methods for selecting bacteriophage therapy based on time and location
  • Systems and methods for selecting bacteriophage therapy based on time and location
  • Systems and methods for selecting bacteriophage therapy based on time and location

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Embodiment Construction

[0025] As used in the specification and the claims, the singular forms "a (a)," "an (an)," and "the (the)" include plural references unless the context clearly dictates otherwise. For example, the term "cell" includes a plurality of cells, including mixtures thereof. The term "nucleic acid molecule" includes a plurality of nucleic acid molecules. A "phage preparation" refers to a preparation comprising at least one phage, as well as multiple phages (ie, more than one phage). As understood by those skilled in the art, the term "phage" can be used to refer to a single phage or to more than one phage.

[0026] The invention can "comprise" (open-ended) or "consist essentially of" the components of the invention and other components or elements described herein. As used herein, "comprising" means the recited elements, or their structural or functional equivalents, plus any other element or elements not recited. The terms "having" and "comprising" are also to be construed as open...

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Abstract

A method of selecting a bacteriophage formulation is described wherein the method comprises storing bacterial infection / contamination data at one or more treatment sites in a spatio-temporal infection database, the database comprising at least one of the following data fields: (1) clinical indications, (2) bacterial identification, (3) clinical effects, (4) bacteriophage resistance status, (5) a bacteriophage resistance status, and (6) a bacteriophage resistance status. (5) a bacteriophage susceptibility attribute, (6) an antibiotic susceptibility attribute, and / or (7) a laboratory test result related to any one of (1) to (6); identifying one or more infections associated with the treatment site during the historical period of time by analyzing the data fields (1) to (7) in the database based at least on one or more of the frequency of infections / contamination, geo-clustering of infections / contamination, and / or bacteriophage usage data, thereby identifying one or more bacteriophages suitable for inclusion in the bacteriophage formulation; and generating a selection list of bacteriophages to be included in the bacteriophage preparation. Uses of the formulations are also described.

Description

technical field [0001] The present disclosure relates to the disposal of bacterial infections and bacterially contaminated surfaces. In a specific form, the present disclosure relates to early intervention using bacteriophage treatment. Background technique [0002] In the following discussion, certain articles and methods will be described for background and introductory purposes. Nothing contained herein should be construed as an "admission" of prior art. Applicants expressly reserve the right, under appropriate circumstances, to demonstrate that the articles and methods cited herein do not constitute prior art under applicable law. [0003] Multidrug-resistant (MDR) bacteria are emerging at an alarming rate. Currently, it is estimated that at least 2 million infections in the United States are caused by MDR organisms each year, resulting in approximately 23,000 deaths. Many MDR infections are hospital-acquired and, in some cases, can be confined to specific units in a...

Claims

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Application Information

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IPC IPC(8): G16H50/20C12Q1/689G16B20/00G16B40/00G16H40/20G16H50/70G16H10/40G16H10/60G16H20/00G16H20/10G16H50/80G16H70/60
CPCG16H50/20G16H40/20G16H20/00G16H10/40G16H70/60Y02A90/10G16H20/10
Inventor 罗布·科恩格雷格·梅里尔
Owner ADAPTIVE PHAGE THERAPEUTICS INC
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