Multi-channel modular animal inhalation exposure box and exposure system

Abstract

The multi-channel modular animal inhalation exposure box comprises a test box, a side door is hinged to a side opening of the test box, a mist inlet, a detection port, an air inlet and an air outlet are formed in the test box, and experimental animals are placed in the test box. The multi-channel modularized animal inhalation exposure box is not only suitable for contamination experiment research with controllable dosage and condition in a laboratory, but also suitable for outdoor exposure research in an actual environment, that is, experimental animals can be exposed to atomized aerosol particles, simulated contamination gas, tail gas, flue gas and the like, and can also be exposed to an external actual atmospheric environment; the animal exposure system is simple in structure and convenient to use, simultaneous exposure research on multiple groups of animals, different target pollutants and different contamination doses can be achieved through modular combination, the exposure system can achieve the purpose of actual environment exposure or specific environment exposure through natural respiration intake of the animals, and convenience and diversity of research are achieved.

Description

technical field [0001] The invention relates to the technical field of exposure experiment devices, in particular to a multi-channel modular animal inhalation exposure box and an exposure system. Background technique [0002] As the World Health Organization gradually tightens health standards for air pollution, research on the health hazards of air pollution is particularly important. The results of the Global Burden of Disease Study in 2019 show that air pollution ranks fourth as the cause of death in the world. Air pollutants can directly or carry a large number of organic chemical components into the bronchi, alveoli and even blood through breathing, thereby affecting the human respiratory system, heart, and heart. Vascular system, immune system, nervous system, etc. Therefore, research on the health effects of air pollution exposure has attracted much attention. However, the existing scientific research results cannot form a comprehensive understanding of the health e...

AI Technical Summary

Problems solved by technology

In some studies, the experimental animals were fixed and exposed to the mouth and nose. The exposure time of this method is limited, and the autonomous activities of the animals are restricted during the exposure process, which cannot avoid interference with the physiological indicators of the animals.

In addition, most air pollutants cause long-term and chronic damage to the body, and the damage caused by one-time large-dose exposure does not conform to the chronic pathological process caused by long-term repeated inhalation of organisms.

[0004] The exposure box can simulate the exposure of animals to air pollutants in the actual environment, but most of the existing whole-body exposure systems are commercial integrated products, which integrate the computer control system, air treatment system and exposure functional units in a large cabinet. Although the exposure parameters are automatically adjusted, the overall price of the product is expensive, the volume is too large, it takes up a lot of space in the laboratory, and it is not easy to move; and this kind of exposure box and exposure system for animal adsorption and poisoning experiments can only be passed through animals. Inhalation exposure, unable to carry out active inhalation exposure in the actual environment

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