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Quality evaluation method for traditional Chinese medicine single-decoction merged substances and application of quality evaluation method

A quality evaluation and material technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of inconsistency, inability to determine the overall quality of single-decoction combined substances and co-decoction substances, so as to ensure consistency, improve the consistency of clinical efficacy and Consistent safety and clinical efficacy

Active Publication Date: 2021-12-07
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the technical problem to be solved in the present invention is to overcome the methods for evaluating single-decoction medicaments in the prior art that use one-sided evaluation methods such as effective / index component content, fingerprint similarity or characteristic spectrum relative retention time or relative peak area, Furthermore, it is impossible to determine whether the single-decoction combined substance and the co-decoction substance are inconsistent as a whole; thereby providing a quality evaluation of a single-decoction combined substance of traditional Chinese medicine that can more easily and accurately judge whether the single-decoction combined substance and the co-decoction substance are more consistent Method and its application

Method used

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  • Quality evaluation method for traditional Chinese medicine single-decoction merged substances and application of quality evaluation method
  • Quality evaluation method for traditional Chinese medicine single-decoction merged substances and application of quality evaluation method
  • Quality evaluation method for traditional Chinese medicine single-decoction merged substances and application of quality evaluation method

Examples

Experimental program
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Effect test

Embodiment 1

[0037] A method for evaluating the quality of combined extracts of Chinese medicine single decoction. In this embodiment, the quality of the single decoction combined substance of the Chinese medicine composition for improving lung inflammation is investigated. The formula of the Chinese medicine composition for improving lung inflammation is: 25 parts of honeysuckle, 25 parts of forsythia, 10 parts of mulberry leaves, 8 parts of chrysanthemum, 25 parts of coix seed, 10 parts of fritillaria, 6 parts of bitter almond. details as follows:

[0038] 1. Preparation of single co-decoction extract

[0039] Single decoction and combined extract: take each herbal decoction piece in the prescription, add 12 times the amount of water each; heat the first decoction for 90 minutes, filter, and collect the filtrate; , combined filtrate, that is.

[0040] Co-decoction extract: take the decoction pieces of each flavor in the prescription, add 12 times the amount of water; heat the first dec...

Embodiment 2

[0064] A method for evaluating the quality of combined substances of traditional Chinese medicine single decoction. The formula of the traditional Chinese medicine composition for improving pulmonary inflammation in this example is: 30 parts of honeysuckle, 30 parts of forsythia, 15 parts of mulberry leaves, 10 parts of chrysanthemum, and 30 parts of coix seed , 15 parts of Zhe Fritillaria, 9 parts of bitter almonds. The specific inspection process is as follows:

[0065] 1. Preparation of single co-decoction concentrate

[0066] Single decoction combined concentrated solution: take each medicinal herb piece in the prescription, decoct them separately, add 10 times the amount of water each; heat and extract for 1st decoction for 60 minutes, filter, and collect the filtrate; add 8 times the amount of water for heating and extracting for 60 minutes for the second decoction , filtered, and the filtrate was collected, concentrated under reduced pressure at 60°C to a relative dens...

Embodiment 3

[0089] A method for evaluating the quality of combined substances of a single decoction of traditional Chinese medicine. The formula of the traditional Chinese medicine composition for improving pulmonary inflammation in this example is: 35 parts of honeysuckle, 35 parts of forsythia, 20 parts of mulberry leaves, 12 parts of chrysanthemum, and 35 parts of coix seed , 20 parts of Zhe Fritillaria, 12 parts of bitter almonds. The specific inspection process is as follows:

[0090] 1. Preparation of single co-decoction granules

[0091] Single decoction combined with granules: Take the decoction pieces of each flavor in the prescription, decoct them separately, and add 14 times the amount of water; the first decoction is heated and extracted for 120 minutes, filtered, and the filtrate is collected; the second decoction is added with 12 times the amount of water, heated and extracted for 120 minutes, Filtrate, collect the filtrate, concentrate under reduced pressure at 60°C to a r...

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Abstract

The invention provides a quality evaluation method of traditional Chinese medicine single-decoction combined substances and application thereof. The quality evaluation method comprises the following steps: evaluating the quality of the single-decoction combined substances at least by adopting a key quality attribute similarity coefficient Scqa of a characteristic spectrum or a fingerprint spectrum as an evaluation index, the evaluation process is as follows: the number of characteristic peaks with the Scqa value range of 0.7-1.3 of the characteristic spectrum or the fingerprint spectrum is more than 80% of the total number of the characteristic peaks, wherein the Scqa value is equal to the ratio of the relative peak area of the S peak corresponding to each characteristic peak in the single decoction combined substance to the relative peak area of the S peak corresponding to each characteristic peak in the co-decoction substance. According to the method, whether the single-decoction combined substance and the co-decoction substance are more consistent or not can be judged more simply, conveniently and accurately.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a method for evaluating the quality of combined substances of a single decoction of traditional Chinese medicines and an application thereof. Background technique [0002] In order to facilitate clinical medication, traditional Chinese medicine formula granules obtained by extracting, concentrating, drying and forming preparations of single decoction pieces emerged as the times require, and are increasingly recognized by the market. The traditional Chinese medicine formula granules are made of decoction pieces, extracted with water, concentrated, dried, and granulated. important practice in development. However, in the traditional Chinese medicine, except for a few varieties that need to be decocted separately, most of them are decocted together with prescription pieces. [0003] However, there are usually differences in the material composition of the extracted sub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/86
CPCG01N30/02G01N30/06G01N30/8679Y02P90/30
Inventor 张志强肖小河王伽伯韩妮娜张萍周永峰李梦荣李纳纳高珊珊付静
Owner BEIJING KANGRENTANG PHARMA
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