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Transcriptomic profiling for prognosis of breast cancer

A technology for breast cancer and prognosis, applied in the fields of analytical materials, biomaterial analysis, microbial determination/testing, etc., which can solve the differences in results, inconsistent levels of individual subjects, different groups of low-risk and high-risk subjects, etc. question

Pending Publication Date: 2021-10-26
PFS GENOMICS INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when considering gene expression trials using baseline risk, an emerging issue is the notion that current trials are inconsistent at the individual subject level
While gene expression assays performed well overall and were similar at the group level, individual subject results could vary widely, i.e. groups of low-risk and high-risk subjects were not the same when different assays were used

Method used

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  • Transcriptomic profiling for prognosis of breast cancer
  • Transcriptomic profiling for prognosis of breast cancer
  • Transcriptomic profiling for prognosis of breast cancer

Examples

Experimental program
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Effect test

Embodiment 1

[0187] Example 1: Comprehensive transcriptome profiling identifies breast cancer subjects who are likely to be exempt from adjuvant systemic therapy.

[0188] Introduction

[0189] In this study, we aimed to better stratify patients with early breast cancer. Factors that can affect the ability of gene expression signatures to successfully stratify subjects by risk include lack of long-term follow-up of large well-defined cohorts of subjects, lack of cohorts of subjects without any systemic therapy, and specific Limited ability to compare results with results obtained for other expression markers. Therefore, this study aimed to address these questions by comprehensively analyzing the transcriptomes of 765 early breast cancer subjects from the SweBCG 91-RT trial, 703 of whom were not systemically treated in the adjuvant setting (Sjostrom M et al. J Clin Oncol 35:3222-3229, 2017). Fifteen different gene expression signatures previously developed for ER+ subjects were calculate...

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Abstract

Methods, systems, and kits for the diagnosis, prognosis, and treatment of breast cancer in a subject are disclosed. The invention also provides biomarkers and clinically useful classifiers for identifying subjects at low risk of breast cancer recurrence who may be spared from adjuvant chemotherapy and endocrine therapy. Further disclosed herein, in certain instances, are probe sets for use in detecting such biomarkers for determining the risk of breast cancer recurrence in a subject. Methods of beating breast cancer based on expression profiling to determine the risk of breast cancer recurrence are also provided.

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 62 / 777,128, filed December 8, 2018, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates to the field of personalized medicine and methods for the treatment of breast cancer. In particular, the present invention relates to the use of transcriptomic profiling for the prognosis of breast cancer to identify subjects who are likely to be exempt from adjuvant systemic therapy. Background technique [0004] Cancer is the uncontrolled growth of abnormal cells anywhere in the body. Abnormal cells are called cancer cells, malignant cells, or tumor cells. Many cancerous and abnormal cells that make up cancerous tissue are further identified by the name of the tissue from which the abnormal cells originate (eg, breast cancer). Cancer cells can proliferate uncontrollably and form cancer cell clumps. Cancer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12Q1/6816G01N33/574G16H50/20
CPCG16H50/20C12Q1/6886G01N33/57415G01N2800/52G16H50/30G16H20/10G16H20/40C12Q2600/158Y02A90/10C12Q1/68C12Q1/6816G01N33/574C12Q2600/118
Inventor S·L·常E·达维乔尼F·冯
Owner PFS GENOMICS INC
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