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Pueraria, scutellaria baicalensis and coptis extract, preparation method, pharmaceutical preparation and application

A technology of pueraria chinensis and pharmaceutical preparations, applied in the field of pueraria chinensis extracts, can solve problems such as potential safety hazards, and achieve the effects of good safety, short time consumption and good reproducibility

Active Publication Date: 2021-10-19
康美华大基因技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to literature reports, long-term use of Coptis chinensis preparations has certain potential safety hazards (Zhao Xiyan, Tong Xiaolin, Zhao Linhua, etc. Progress in modern research on Coptis unilateral prescriptions and adverse reactions of their main components. Chinese Journal of Traditional Chinese Medicine, 2013, 38(2): 292-295.)

Method used

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  • Pueraria, scutellaria baicalensis and coptis extract, preparation method, pharmaceutical preparation and application
  • Pueraria, scutellaria baicalensis and coptis extract, preparation method, pharmaceutical preparation and application
  • Pueraria, scutellaria baicalensis and coptis extract, preparation method, pharmaceutical preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation method of the Pueraria chinensis extract of the present embodiment comprises the following steps:

[0047] Step 1): Take Pueraria lobata, Scutellaria baicalensis, Coptis chinensis and Zhigancao according to the weight ratio of 8:3:3:2, heat and reflux with water to extract twice, and the amount of water added each time is 8 times and 6 times the total weight of the above raw materials respectively, each time The extraction time was 1.5 hours and 1 hour, respectively, and the two extracts were combined to obtain the total extract after filtration. Concentrate the total extract under reduced pressure below 85°C, recover the solvent, and obtain the primary extract of Pueraria baicalensis.

[0048] Step 2): use preparative liquid chromatography to remove berberine in the primary extract of Pueraria chinensis. Preparative liquid chromatography with C 18 Silica gel was used as filler (Agilent Prep-C18, 21.2mm×250mm, 5 μm), 0.1% formic acid-water was used as ...

Embodiment 2

[0053] Get the first extract of Pueraria chinensis prepared in step 1) of Example 1, filter and go to C 18 Silica gel preparative liquid chromatography (Agilent Prep-C18, 21.2mm × 250mm, 5μm), with methanol as mobile phase A, water as mobile phase B, gradient elution (0 ~ 60min, 10% ~ 100% A), the flow rate is 10ml / min, the column temperature is room temperature, and an ultraviolet detector is used for detection, and the detection wavelength is 346nm. Determine the resolution of berberine from adjacent chromatographic peaks.

Embodiment 3

[0055] Get the first extract of Pueraria chinensis prepared in step 1) of Example 1, filter and go to C 18 Silica gel preparative liquid chromatography (Agilent Prep-C18, 21.2mm × 250mm, 5 μ m), with ethanol as mobile phase A, water as mobile phase B, gradient elution (0 ~ 60min, 10% ~ 100% A), the flow rate is 10ml / min, the column temperature is room temperature, and an ultraviolet detector is used for detection, and the detection wavelength is 346nm. Determine the resolution of berberine from adjacent chromatographic peaks.

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Abstract

The invention discloses a pueraria, scutellaria baicalensis and coptis extract, a preparation method, a pharmaceutical preparation and application. The pueraria, scutellaria baicalensis and coptis extract is a water extract of radix puerariae, scutellaria baicalensis, coptis and liquorice roots according to a weight ratio of 8: 3: 3: 2, and the extract does not contain berberine. The provided extract not only retains the effective components of radix puerariae, scutellaria baicalensis, coptis and liquorice roots, but also does not contain berberine, and the drug effect is superior to that of a pueraria, scutellaria baicalensis and coptis extract that contains berberine.

Description

technical field [0001] The present invention relates to an extract of Pueraria chinensis, a preparation method, a pharmaceutical preparation and its use, in particular to an extract extracted from Pueraria baicalensis, Scutellaria baicalensis, Coptis chinensis and licorice, a preparation method of the extract, and a medicine containing the extract Preparation, and the purposes of this extract. Background technique [0002] Gegen Qinlian Decoction is one of the classic ancient prescriptions. It comes from Article 34 of "Treatise on Febrile Diseases" written by Zhang Zhongjing in the late Eastern Han Dynasty: "Taiyang disease, osmanthus twig disease, if the doctor reverses it, the symptoms will not stop, and the pulse will not be solved. , panting and sweating, Gegen Huangqin Huanglian Decoction is the main one." Its composition is: half a catty of kudzu root, 2 liang of licorice (burned), 3 liang of Scutellaria baicalensis, and 3 liang of Coptis chinensis. Gegen Qinlian Dec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P3/00A61P3/04A61P3/06A61P3/10A61P9/12
CPCA61K36/488A61K36/539A61K36/718A61K36/484A61P3/00A61P3/04A61P3/06A61P3/10A61P9/12A61K2236/331A61K2236/39A61K2300/00
Inventor 李宁郭筱璐江亚勇王丽赖秋梅孙彦平韩丽娟
Owner 康美华大基因技术有限公司
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