Clinical prognosis prediction model before surgical operation of initial non-resectable hepatocellular carcinoma

Abstract

The invention relates to a clinical prognosis prediction model before surgical operation of initial non-resectable hepatocellular carcinoma, and belongs to the technical field of biological medicine. The prediction model is a Nomogram model constructed based on Cox regression analysis of pre-surgical data; the model comprises five key influence factors including SLR prealpha fetoprotein, the number of cancerous lesions, portal vein cancerous embolus, the maximum diameter of a main tumor and tumor load change after TACE treatment. Through the SLR pre-operation selection of the prognosis prediction model for initial non-resection HCC in TACE + SLR treatment, people which can better survive and benefit from SLR can be screened out, and clinical guidance is provided for selection of patients suitable for remedy liver resection after TACE treatment; and accurate and individualized long-term survival prediction can be carried out on HCC patients who are ready to receive remedial liver resection treatment before surgical operation, so that more accurate individualized treatment of liver cancer is facilitated.

Description

technical field [0001] The invention relates to a clinical prognosis prediction model before surgery for initial unresectable hepatocellular carcinoma, belonging to the technical field of biomedicine. Background technique [0002] Hepatocellular carcinoma (Hepatocellular carcinoma, HCC) accounts for about 85%-90% of primary liver cancer, and "liver cancer" in the present invention specifically refers to HCC. The number of new patients with HCC worldwide is about 800,000 every year, ranking second in the cause of cancer death. In China, HCC is the fourth most common malignant tumor and the second leading cause of cancer death. Nearly 50% of the newly discovered patients in the world are in my country, so it poses a great threat to the life and health of our people. Different from western countries, HCC patients in my country have unique characteristics in eastern countries. HBV infection (more than 80%) is the main cause, and HCV infection and other non-infectious causes acc...

AI Technical Summary

Problems solved by technology

At present, although liver resection is the first choice for the treatment of early-stage HCC, less than 1 / 3 of patients with primary HCC in my country can undergo surgical resection because most patients are diagnosed late.

Currently, there is no report on a simple, reliable and practical SLR preoperative prognosis prediction model for TACE+SLR treatment of initially unresectable HCC population

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