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Identifying responsiveness to radio-immuno combination therapy

A reactive, immunotherapeutic technique with applications in mechanical/radiation/invasive therapy, microbiological determination/inspection, computer-assisted medical procedures, etc.

Pending Publication Date: 2021-09-17
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no known tools to assist clinicians in selecting successful therapies that will elicit tumor responses to radiation in a manner that stimulates an adaptive immune response using radiation in combination with immunotherapy (eg, immune checkpoint inhibition)

Method used

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  • Identifying responsiveness to radio-immuno combination therapy
  • Identifying responsiveness to radio-immuno combination therapy
  • Identifying responsiveness to radio-immuno combination therapy

Examples

Experimental program
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Embodiment Construction

[0025] A combination of radiation therapy and immunotherapy holds hope for a large number of patients battling advanced cancer. Described herein is an automated method that enables tailoring of tumor treatment by determining responsiveness based on biomarker expression in tumors, and identifies which should be selected for combined radio-immunotherapy treatment. An analysis of responsiveness to the available possible radiotherapy treatment modalities (eg, standard, accelerated, hypofractionated, ablative high-dose) is also described.

[0026]Recent studies have shown that hypofractionated radiation therapy can stimulate absitual responses (immune cell responses to tumor antigens) more effectively than high-dose single radiation therapy when combined with cytotoxic T lymphocyte antigen 4 (CTLA-4) immunotherapy. start up). A possible explanation for this finding is the finding that type I interferon (IFN-β) signaling derived from irradiated tumor cells is critical for BATF3-dep...

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PUM

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Abstract

Described is a computer-implemented method for identifying responsiveness to therapy for a subject suffering from cancer. The method involves determining values of biomarkers such as the levels of TREX1, PD-L1 and / or immune cell infiltration in a cancerous lesion. The biomarker values are processed to obtain a score indicative of responsiveness of the cancerous lesion to combined radio- and immunotherapy treatment. The method may obtain scores for multiple treatment modalities (such as different doses and / or fractionations of radiotherapy) and / or different cancer lesions in the subject. Also provided is a system and computer program product for performing the method.

Description

technical field [0001] Embodiments described herein relate generally to methods, systems, and computer program products for identifying responsiveness to cancer therapy. The method is particularly useful for determining responsiveness to combined radiation therapy and immunotherapy treatment, and can be used to select a particular treatment modality for the treatment of a subject. For example, the method can be applied to determine a preferred dose and / or fractionation of radiation therapy used in combination with immunotherapy, and / or to select a preferred cancerous lesion to be treated in a subject in order to generate a distant response. Background technique [0002] Diagnosis and treatment decisions in oncology are largely based on the underlying biology. Understanding the mechanisms of disease plays a key role in cancer research and can also help clinicians make decisions and track disease progression. [0003] Radiation therapy (RT) has been used for more than a cent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H20/10G16H20/40G16H50/30C12Q1/6886
CPCG16H20/10G16H20/40G16H50/30C12Q1/6886C12Q2600/106C12Q2600/158
Inventor P·罗德里格斯V·L·D·C·维托里诺·德阿尔梅达R·维姆贝格-弗雷德尔
Owner KONINKLJIJKE PHILIPS NV
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