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Method for establishing prognosis model for treating advanced liver cancer patients by HAIC

A prediction model, prognosis technology, applied in the medical field, can solve the problem of different efficacy

Pending Publication Date: 2021-09-07
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, hepatic arterial infusion chemotherapy containing FOLFOX (5-FU, leucovorin, and oxaliplatin) has been used in many domestic hospitals for the treatment of advanced liver cancer, but the curative effects of each report are different.
There is great controversy about which patients are suitable for hepatic arterial infusion chemotherapy

Method used

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  • Method for establishing prognosis model for treating advanced liver cancer patients by HAIC
  • Method for establishing prognosis model for treating advanced liver cancer patients by HAIC
  • Method for establishing prognosis model for treating advanced liver cancer patients by HAIC

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Embodiment Construction

[0033] The features of the present invention and other relevant features are described in further detail below in conjunction with the accompanying drawings through the embodiments, so as to facilitate the understanding of those skilled in the art:

[0034] Embodiments of the present invention include a method for establishing a prognosis model for patients with advanced liver cancer treated with HAIC, through which the prognosis model for patients with locally advanced liver cancer who receive hepatic artery infusion chemotherapy can be obtained, and the method specifically includes:

[0035] a) Sample data collection

[0036] The present invention includes 130 patients with locally advanced liver cancer who were diagnosed with locally advanced liver cancer in the Department of Liver Oncology, Zhongshan Hospital Affiliated to Fudan University from September 2018 to January 2021, and received hepatic artery infusion chemotherapy with the modified FOLFOX regimen.

[0037] b) Sc...

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Abstract

The invention discloses a method for establishing a prognosis model for treating advanced liver cancer patients by HAIC, which comprises the following steps: (1) acquiring sample data, and screening the sample data; (2) carrying out single-factor analysis and multi-factor analysis by adopting a Cox proportional danger model, and selecting factors influencing prognosis from the sample data; (3) establishing a column graph prediction model for predicting prognosis according to the sample data and the factors influencing prognosis; and (4) verifying the column graph prediction model by adopting c-index and a correction curve. The model established by the method can evaluate the hepatic artery perfusion chemotherapy prognosis model of the local advanced liver cancer patient, and the model is displayed in the form of a column diagram, so that the model is intuitive and simple, and is convenient for clinical doctors and patients to operate and carry out individualized prediction on the patients.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for establishing a prognosis model for patients with advanced liver cancer treated with HAIC. Background technique [0002] Hepatocellular carcinoma (hereinafter referred to as liver cancer) is the second leading cause of cancer death in my country, and the number of deaths due to liver cancer is close to 400,000 every year. More than 70% of liver cancer patients are in the advanced stage when they are discovered, and lose the chance of surgical treatment, and the median survival time is 4.2-7.9 months. Hepatic arterial infusion chemotherapy is mainly used for the treatment of advanced liver cancer. Its advantage is that high-concentration chemotherapy drugs can be directly delivered to the liver to kill tumors, while reducing systemic adverse reactions. It is mainly used for advanced liver cancer patients with vascular tumor embolism. Patients with metastases have limited effic...

Claims

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Application Information

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IPC IPC(8): G16B5/00G16H50/50
CPCG16H50/50G16B5/00
Inventor 许书榕陈荣新徐馨陈茂培张岚任正刚
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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