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Maternal dpa for benefit of mother and/or child's mental health

A child, effective dose of technology, applied in the field of postpartum depression, can solve the problem of poor understanding of DPA

Pending Publication Date: 2021-08-24
AGENCY FOR SCI TECH & RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] While much research has been done on the effects of DHA and EPA, little is known about DPA

Method used

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  • Maternal dpa for benefit of mother and/or child's mental health
  • Maternal dpa for benefit of mother and/or child's mental health
  • Maternal dpa for benefit of mother and/or child's mental health

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Embodiment Construction

[0006] In light of our invention, we have found clear evidence of a relationship between maternal emotional health, placental lipidome, and children's socio-emotional development, suggesting that emotion-linked changes in the mother's nutritional status affect availability to the fetus. Our longitudinal analyzes intricately identified that a subset of placental lipids associated with maternal mood were also associated with socioemotional outcomes in offspring. Reduced levels of key placental lipids were also confirmed by low DPA levels in maternal plasma at 26 weeks' gestation, the time point at which antenatal depression was assessed. These findings suggest that nutritional manipulation may be an effective intervention in women with antenatal depression in terms of preventing subsequent suboptimal neurodevelopment of offspring.

[0007] Accordingly, one embodiment of the present invention is a method of reducing the risk of depression, preventing or ameliorating the symptoms ...

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Abstract

This is the first ever report to uncover a tangible lipidomic basis by which maternal emotional well-being may influence fetal neuro-development and the later risk for psychopathology. This novel insight points to the potential utility of nutritional approaches among pregnant women with high levels of depressive symptoms in the prevention of offspring risk for later socio-emotional behavioral problems predictive of future psychopathology. Such a novel approach is particularly pertinent in light of the preference to avoid pharmacological interventions such as anti-depressant medications during pregnancy.

Description

Contents of the invention [0001] The present invention relates to the prenatal administration of polyunsaturated fatty acids (PUFAs), preferably including docosapentaeonic acid (DPA), to protect children from adverse mental health and to protect mothers from depression disorders, including postpartum depression. The present invention also relates to formulations comprising DPA as an active ingredient; and compositions comprising DPA and another active ingredient beneficial to pregnant women. Background technique [0002] A variety of polyunsaturated fatty acids (PUFAs) play nutritional roles throughout life. [0003] While much research has been done on the effects of DHA and EPA, little is known about DPA. Li et al., 2016 Eur J Lipid Sci Tech. 118:1692-1701 review many aspects, including the observation that lower blood DPA levels are associated with increased incidence of mental health disorders, including depression. It is also known that DPA has anti-inflammatory effe...

Claims

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Application Information

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IPC IPC(8): A61K31/202A61P25/00A61P25/22A61P25/24A61P25/28
CPCA61K31/202A61P25/00A61P25/22A61P25/24A61P25/28A61P3/02
Inventor 内尔哈·卡纳尼黄锦平彼得·大卫·格鲁克曼迈克尔·约瑟夫·米尼
Owner AGENCY FOR SCI TECH & RES
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