A degradable self-healing conductive hydrogel and its preparation method and application

A conductive hydrogel and self-healing technology, which is applied in the fields of biomedical materials and biomedical engineering, can solve problems such as limited applications, and achieve good electrical signal conduction performance, good nerve repair performance, and enhanced mechanical properties

Active Publication Date: 2022-03-11
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, researchers have explored conductive hydrogels based on conductive polymers such as polyaniline (PANI), polypyrrole (PPY) and poly(3,4-ethylenedioxythiophene), but Due to their limitations in biocompatibility and degradability, their application in the field of tissue engineering is further restricted

Method used

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  • A degradable self-healing conductive hydrogel and its preparation method and application
  • A degradable self-healing conductive hydrogel and its preparation method and application
  • A degradable self-healing conductive hydrogel and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0030] 1) Prepare a 2 mg / mL hyaluronic acid solution, add 956 mg EDC·HCl and 574 mg N-hydroxysuccinimide (NHS) to activate the hyaluronic acid solution for 15 minutes, and dissolve 843 mg of cystamine dihydrochloride (CSA) Obtain cystamine dihydrochloride solution in 50mL deionized water, drop 500mL hyaluronic acid solution into cystamine dihydrochloride solution, react for 8 hours, dialyze for 3 days, and obtain purified cystamine dihydrochloride-hyaluronic acid acid (CSA-HA); and then prepare a purified cystamine dihydrochloride-hyaluronic acid solution with a concentration of 2 mg / mL.

[0031] 2) Dissolve 347mg of pyrrole-1-propionic acid (Py) in 50ml of deionized water to obtain a pyrrole-1-propionic acid solution, add 476mg of EDC·HCl to activate the pyrrole-1-propionic acid solution for 15 minutes, then add step 1) configuration The obtained purified CSA-HA solution was reacted for 8 hours, dialyzed for 3 days, and freeze-dried to obtain purified pyrrole-1-propionic acid...

Embodiment 2

[0037]1) Prepare a 3 mg / mL hyaluronic acid solution, add 1434 mg EDC·HCl and 861 mg NHS to activate the hyaluronic acid solution for 20 minutes, dissolve 1264 mg of cystamine dihydrochloride (CSA) in 75 mL of deionized water to obtain cystamine di-salt salt solution, drop 500mL hyaluronic acid solution into cystamine dihydrochloride solution and react for 9 hours, dialyze for 4 days to obtain purified cystamine dihydrochloride-hyaluronic acid (CSA-HA); then configure the concentration Purified cystamine dihydrochloride-hyaluronic acid solution at 2 mg / mL.

[0038] 2) Dissolve 520 mg of pyrrole-1-propionic acid (Py) in 75 mL of deionized water to obtain pyrrole-1-propionic acid solution, prepare 714 mg of EDC·HCl activated pyrrole-1-propionic acid solution for 20 minutes, add step 1) configuration The obtained purified CSA-HA solution was reacted for 9 hours, dialyzed for 4 days, and freeze-dried to obtain purified pyrrole-1-propionic acid-cystamine dihydrochloride-hyaluronic a...

Embodiment 3

[0041] 1) Prepare 3.5 mg / mL hyaluronic acid solution, add 1673 mg EDC·HCl and 1004 mg NHS activated hyaluronic acid solution for 25 minutes, dissolve 1475 mg cystamine dihydrochloride (CSA) in 85 mL deionized water to obtain cystamine dihydrochloride (CSA) Hydrochloride solution, drop 500mL hyaluronic acid solution into cystamine dihydrochloride solution and react for 10 hours, dialyze for 5 days to obtain purified cystamine dihydrochloride-hyaluronic acid (CSA-HA); then configure Purified cystamine dihydrochloride-hyaluronic acid solution at a concentration of 2 mg / mL.

[0042] 2) Dissolve 607 mg of pyrrole-1-propionic acid (Py) in 85 mL of deionized water to obtain a pyrrole-1-propionic acid solution, prepare 833 mg of EDC·HCl to activate the pyrrole-1-propionic acid solution for 25 minutes, add step 1) to configure The purified CSA-HA solution was reacted for 10 hours, dialyzed for 5 days, and freeze-dried to obtain purified pyrrole-1-propionic acid-cystamine dihydrochlorid...

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Abstract

The invention discloses a degradable self-healing conductive hydrogel and its preparation method and application. The preparation method comprises modifying cystamine dihydrochloride (CSA) on the branched chain of hyaluronic acid (HA) through an amide bond, Obtain cystamine dihydrochloride-hyaluronic acid (CSA-HA); modify pyrrole-1-propionic acid (Py) on the CSA of CSA-HA through an amide bond to obtain pyrrole-1-propionic acid-cystamine di Hydrochloride‑hyaluronic acid (Py‑CSA‑HA); soak Py‑CSA‑HA in a ferric chloride solution after self-forming gel, so that Py can be polymerized into polypyrrole (PPy), and degradable self-healing conductive hydrogel can be obtained glue. The method provided by the present invention is simple and effective, and easy to operate. Because the hydrogel has self-repairing, degradable and conductive functions, it is applied to nerve repair biological tissue materials, especially conductive nerve scaffold materials, which have better nerve repair performance and electrical signal conduction. performance.

Description

technical field [0001] The invention belongs to the technical fields of biomedical materials and biomedical engineering, and relates to a degradable self-repairing conductive hydrogel and a preparation method and application thereof. Background technique [0002] Peripheral nerve injury (PNI) occurs in the aging population, iatrogenic side effects, and acute trauma, and can lead to loss of motor function, muscle paralysis, and even lifelong disability. It is estimated that there are more than 5 million cases of PNI worldwide each year. Therefore, there is an urgent need to develop effective strategies for PNI repair. Peripheral nerve cells grow throughout our lives. Nerve tissue engineering technology has broad application prospects in the repair and recovery of motor and sensory functions. It utilizes natural or synthetic materials as implanted nerve conduits or scaffolds for nerve cell growth. This material has suitable mechanical properties to support soft neural tiss...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L5/08C08L79/04C08K3/16C08B37/08C08G73/06A61L27/20A61L27/18A61L27/52A61L27/58
CPCC08J3/075C08B37/0072C08G73/0611A61L27/52A61L27/58A61L27/20A61L27/18A61L2430/32C08L5/08C08L79/04C08K3/16C08J2305/08C08J2479/04
Inventor 宣红云吴淑嫄袁卉华李碧云杨宇民
Owner NANTONG UNIVERSITY
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