Degradable self-repairing conductive hydrogel, preparation method and application thereof

A conductive hydrogel, self-healing technology, applied in the fields of biomedical materials and biomedical engineering, can solve problems such as limited application, and achieve the effects of good electrical signal conduction performance, good biocompatibility, and favorable electrical conductivity

Active Publication Date: 2021-06-29
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, researchers have explored conductive hydrogels based on conductive polymers such as polyaniline (PANI), polypyrrole (PPY) and poly(3,4-ethylenedioxythiophene), but Due to their limitations in biocompatibility and degradability, their application in the field of tissue engineering is further restricted

Method used

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  • Degradable self-repairing conductive hydrogel, preparation method and application thereof
  • Degradable self-repairing conductive hydrogel, preparation method and application thereof
  • Degradable self-repairing conductive hydrogel, preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0030] 1) Prepare a 2 mg / mL hyaluronic acid solution, add 956 mg EDC·HCl and 574 mg N-hydroxysuccinimide (NHS) to activate the hyaluronic acid solution for 15 minutes, and dissolve 843 mg of cystamine dihydrochloride (CSA) Obtain cystamine dihydrochloride solution in 50mL deionized water, drop 500mL hyaluronic acid solution into cystamine dihydrochloride solution, react for 8 hours, dialyze for 3 days, and obtain purified cystamine dihydrochloride-hyaluronic acid acid (CSA-HA); and then prepare a purified cystamine dihydrochloride-hyaluronic acid solution with a concentration of 2 mg / mL.

[0031] 2) Dissolve 347mg of pyrrole-1-propionic acid (Py) in 50ml of deionized water to obtain a pyrrole-1-propionic acid solution, add 476mg of EDC·HCl to activate the pyrrole-1-propionic acid solution for 15 minutes, then add step 1) configuration The obtained purified CSA-HA solution was reacted for 8 hours, dialyzed for 3 days, and freeze-dried to obtain purified pyrrole-1-propionic acid...

Embodiment 2

[0037]1) Prepare a 3 mg / mL hyaluronic acid solution, add 1434 mg EDC·HCl and 861 mg NHS to activate the hyaluronic acid solution for 20 minutes, dissolve 1264 mg of cystamine dihydrochloride (CSA) in 75 mL of deionized water to obtain cystamine di-salt salt solution, drop 500mL hyaluronic acid solution into cystamine dihydrochloride solution and react for 9 hours, dialyze for 4 days to obtain purified cystamine dihydrochloride-hyaluronic acid (CSA-HA); then configure the concentration Purified cystamine dihydrochloride-hyaluronic acid solution at 2 mg / mL.

[0038] 2) Dissolve 520 mg of pyrrole-1-propionic acid (Py) in 75 mL of deionized water to obtain pyrrole-1-propionic acid solution, prepare 714 mg of EDC·HCl activated pyrrole-1-propionic acid solution for 20 minutes, add step 1) configuration The obtained purified CSA-HA solution was reacted for 9 hours, dialyzed for 4 days, and freeze-dried to obtain purified pyrrole-1-propionic acid-cystamine dihydrochloride-hyaluronic a...

Embodiment 3

[0041] 1) Prepare 3.5 mg / mL hyaluronic acid solution, add 1673 mg EDC·HCl and 1004 mg NHS activated hyaluronic acid solution for 25 minutes, dissolve 1475 mg cystamine dihydrochloride (CSA) in 85 mL deionized water to obtain cystamine dihydrochloride (CSA) Hydrochloride solution, drop 500mL hyaluronic acid solution into cystamine dihydrochloride solution and react for 10 hours, dialyze for 5 days to obtain purified cystamine dihydrochloride-hyaluronic acid (CSA-HA); then configure Purified cystamine dihydrochloride-hyaluronic acid solution at a concentration of 2 mg / mL.

[0042] 2) Dissolve 607 mg of pyrrole-1-propionic acid (Py) in 85 mL of deionized water to obtain a pyrrole-1-propionic acid solution, prepare 833 mg of EDC·HCl to activate the pyrrole-1-propionic acid solution for 25 minutes, add step 1) to configure The purified CSA-HA solution was reacted for 10 hours, dialyzed for 5 days, and freeze-dried to obtain purified pyrrole-1-propionic acid-cystamine dihydrochlorid...

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Abstract

The invention discloses a degradable self-repairing conductive hydrogel, a preparation method and application thereof. The preparation method comprises the following steps: modifying cystamine dihydrochloride (CSA) on a branched chain of hyaluronic acid (HA) through an amido bond to obtain cystamine dihydrochloride-hyaluronic acid (CSA-HA); modifying pyrrole-1-propionic acid (Py) on CSA of CSA-HA through an amido bond to obtain pyrrole-1-propionic acid-cystamine dihydrochloride-hyaluronic acid (Py-CSA-HA); and soaking in a ferric chloride solution after the Py-CSA-HA is self-formed into gel, so that Py is polymerized into polypyrrole (PPy), and the degradable self-repairing conductive hydrogel is obtained. The method provided by the invention is simple and effective, the operation is simple and convenient, and the hydrogel has self-repairing, degradable and conductive functions, so that the hydrogel has better nerve repairing performance and electrical signal conduction performance when being applied to the aspect of nerve repairing biological tissue materials, especially conductive nerve scaffold materials.

Description

technical field [0001] The invention belongs to the technical fields of biomedical materials and biomedical engineering, and relates to a degradable self-repairing conductive hydrogel and a preparation method and application thereof. Background technique [0002] Peripheral nerve injury (PNI) occurs in the aging population, iatrogenic side effects, and acute trauma, and can lead to loss of motor function, muscle paralysis, and even lifelong disability. It is estimated that there are more than 5 million cases of PNI worldwide each year. Therefore, there is an urgent need to develop effective strategies for PNI repair. Peripheral nerve cells grow throughout our lives. Nerve tissue engineering technology has broad application prospects in the repair and recovery of motor and sensory functions. It utilizes natural or synthetic materials as implanted nerve conduits or scaffolds for nerve cell growth. This material has suitable mechanical properties to support soft neural tiss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/08C08L79/04C08K3/16C08B37/08C08G73/06A61L27/20A61L27/18A61L27/52A61L27/58
CPCC08J3/075C08B37/0072C08G73/0611A61L27/52A61L27/58A61L27/20A61L27/18A61L2430/32C08L5/08C08L79/04C08K3/16C08J2305/08C08J2479/04
Inventor 宣红云吴淑嫄袁卉华李碧云杨宇民
Owner NANTONG UNIVERSITY
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