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Method and system for evaluating drug resistance of nitrates

A nitrate, drug-resistant technology for medical applications

Pending Publication Date: 2021-06-08
BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, since there is no standardized assessment method for nitrate resistance, establishing an effective assessment method for nitrate resistance is not only of great significance for improving drug research and development, but also of great clinical significance and social value

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  • Method and system for evaluating drug resistance of nitrates

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Embodiment Construction

[0044] The following will refer to the attached figure 1 Specific examples of the present invention are described in more detail. Although specific embodiments of the invention are shown in the drawings, it should be understood that the invention may be embodied in various forms and is not limited to the embodiments set forth herein. Rather, these embodiments are provided for more thorough understanding of the present invention and to fully convey the scope of the present invention to those skilled in the art.

[0045] In order to facilitate the understanding of the embodiments of the present invention, further explanations will be given below in conjunction with the accompanying drawings by taking specific embodiments as examples, and each drawing does not constitute a limitation to the embodiments of the present invention.

[0046] Such as figure 1 As shown, in one embodiment, the present invention discloses a method for evaluating nitrate resistance, comprising the follow...

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Abstract

The invention discloses a method and a system for evaluating drug resistance of nitrates. The method and the system have a core conception that characteristics of nitroglycerin and rapid onset characteristic of sublingual administration are ingeniously utilized, a reference is established in order to reduce influence of drug residues as much as possible, so that rapid detection is realized, core indexes, namely a second vasodilation index d2 and a fourth vasodilation index d4, are ensured to be established on the premise that no significant difference exists in statistical significance between a first vasodilation index d1 and a third vasodilation index d3, so that a ratio of the d4 to the d2 is persuasive, and whether drug resistance occurs or not is judged according to the ratio of the d4 to the d2. The method and the system has characteristics of simplicity, safety and harmlessness, and can be used for guiding further research and development of nitrate drugs so as to optimize drug resistance indexes of the nitrate drugs.

Description

technical field [0001] The invention belongs to the medical field, in particular to an evaluation method and system for nitrate drug resistance. Background technique [0002] Nitrates are the most widely used anti-ischemic drugs in modern times. Nitrate drugs have been used clinically for more than 130 years, and their safety and effectiveness in the treatment of myocardial ischemia have been tested historically, showing strong vitality. In clinical practice, nitrates are often used in the treatment of acute coronary syndrome, chronic stable angina, asymptomatic myocardial ischemia, acute and chronic heart failure, hypertensive crisis, perioperative hypertension, PCI surgery or coronary Used during radiography. [0003] Nitrate drugs mainly include: nitroglycerin, isosorbide dinitrate, isosorbide mononitrate and so on. Nitroglycerin is mainly used to control ischemic attacks, and isosorbide dinitrate and isosorbide mononitrate are mainly used to prevent ischemic attacks. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K49/0004
Inventor 张慧娜聂绍平
Owner BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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