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Application of short peptide asp-his-tyr in preparation of medicine for treating endometriosis

A technology of asp-his-tyr and endometrium, applied in the field of biomedicine, can solve problems such as large side effects, achieve the effect of alleviating abdominal pain and improving endometriosis

Active Publication Date: 2021-08-31
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (2) Danazol is a derivative of androgen in pseudomenopausal therapy, which has better effect, but has relatively large side effects

Method used

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  • Application of short peptide asp-his-tyr in preparation of medicine for treating endometriosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Establishment of animal models of endometriosis

[0022] In the study of endometriosis, the acquisition of endometriosis tissue from clinical patients is limited, so it is necessary to establish animal models of endometriosis. The inventor selected 45 mature female SD rats of SPF grade to establish endometriosis models, and it was identified that 32 SD rats were successfully modeled, with a success rate of 71%. Concrete animal experiment steps (referring to CN102988401A) are as follows:

[0023] (1) 45 sexually mature SPF-level healthy unmated female SD rats were obtained from the Animal Center of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine;

[0024] (2) 1% pentobarbital sodium (40mg / kg) intraperitoneal injection anesthesia;

[0025] (3) After routine disinfection, take the middle of the rat's lower abdomen and 1 cm above the pubic symphysis to make a longitudinal incision of about 3 cm;

[0026] (4) Find the uterus on the...

Embodiment 2

[0040] Examination of the therapeutic effect of short peptide Asp-His-Tyr on endometriosis

[0041] Drugs used:

[0042] Gestrinone: Gestrinone capsules produced by Beijing Zizhu Pharmaceutical Company, dissolved in normal saline. Short peptide Asp-His-Tyr: Synthesized and sequenced by Shanghai Sangon, the short peptide was diluted with normal saline to 10 μg / kg.

[0043] Experimental steps:

[0044]The 32 SD rats successfully modeled were randomly divided into 3 groups (10 rats in each group, and the remaining 2 rats were fed normally), i.e., 10 rats in the negative control group (normal saline infusion group), 10 rats in the positive control group (gestrinone group). In the feeding group, 10 rats (0.5 mg / kg per day), and in the short peptide Asp-His-Tyr injection group (10 ml / kg per day), 10 rats. The volume of normal saline in the control group was the same as that in the short peptide Asp-His-Tyr injection group for 4 consecutive weeks.

[0045] Four weeks later, anoth...

Embodiment 3

[0055] Embodiment 3 clinical trials

[0056] 1 information

[0057] 1.1 General Information

[0058] A total of 80 patients who visited the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from June 2019 to October 2019 were selected and divided into two groups by random number table method, namely the treatment group and the control group, with 40 patients in each group. There was no significant difference in gender, age, course of disease, etc. between the two groups before treatment, and the balance between the groups was good and comparable.

[0059] 1.2 Diagnostic criteria

[0060] According to the standards stipulated by the third academic meeting of the Obstetrics and Gynecology Professional Committee of the Chinese Association of Integrative Medicine and the "Guiding Principles for Clinical Research of New Chinese Medicines for the Treatment of EM", the following diagnostic criteria are drawn up:

[0061] ① Progressive dysmenorrhe...

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Abstract

The invention relates to the application of the short peptide Asp-His-Tyr in the preparation of medicines for treating endometriosis. The short peptide Asp-His-Tyr of the present invention can improve endometriosis, and is particularly suitable for alleviating abdominal pain and / or abnormal menstruation caused by endometriosis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of short peptide Asp-His-Tyr in the preparation of medicine for treating endometriosis. Background technique [0002] Endometriosis is a common gynecological disease in women that is caused by active endometrial cells growing outside the endometrium. Endometrial cells should grow in the uterine cavity, but because the uterine cavity communicates with the pelvic cavity through the fallopian tubes, endometrial cells can enter the pelvic cavity through the fallopian tubes for ectopic growth. At present, there are many theories about the pathogenesis of this disease, among which the theory of endometrium implantation is generally accepted. The disease mostly occurs in women of childbearing age. It does not develop before puberty, and the ectopic lesions can gradually shrink and degenerate after menopause. The main pathological changes of endometriosi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/06A61P15/00
Inventor 韩亚光朱小琳韩延华韩晗
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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