Application of N-terminal DDR1 polypeptide

A technology of usage and content, applied in the medical field, can solve problems such as poor tolerance, doubts about the applicability of reference standards for liver fibrosis, and expensive surgery costs, and achieve the effect of simple operation

Pending Publication Date: 2021-01-29
TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Inherent defects of this procedure, such as errors in biopsy specimen sampling caused by different operators, high cost of surgery, bleeding, biliary fistula and other complications caused by invasive surgery, these problems lead to poor tolerance and low reproducibility
Calling into question its applicability as a reference standard for liver fibrosis

Method used

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  • Application of N-terminal DDR1 polypeptide
  • Application of N-terminal DDR1 polypeptide
  • Application of N-terminal DDR1 polypeptide

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Embodiment Construction

[0020] DDR1 is a member of the receptor tyrosine kinase family, and its ligand is collagen. DDR1 plays an important role in tissue fibrosis and is an attractive anti-fibrotic target. Studies have shown that collagen activates DDR1 to aggregate and enhance its binding to collagen, and DDR1 allows collagen remodeling to promote fibrosis. After collagen binding, DDR1 can be shed through the mediation of membrane-anchored membrane-type collagenase (MT) 1, MT2 and MT3 matrix metalloproteinase (MMP). Collagen causes specific stimulation of the shedding of the extracellular end of DDR1, but does not affect other transmembrane proteins. Collagen-stimulated shedding of the extracellular DDR1 domain has been demonstrated in many studies. Collagen is the most abundant extracellular matrix in the human body. In tissue fibrosis, increased deposition, alignment, and crosslinking of localized collagen fibers lead to tissue hardening. In the dynamic synthesis of extracellular matrix, incl...

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Abstract

The invention discloses an application of N-terminal DDR1 polypeptide, and belongs to the technical field of medical treatment. The degree of hepatic fibrosis is judged by detecting the content of theN-terminal DDR1 polypeptide. According to the new application of the N-terminal DDR1 polypeptide provided by the invention, the liver fibrosis degree can be judged by detecting the content of the N-terminal DDR1 polypeptide in serum, and the method is simple and convenient to operate, is a non-invasive detection method, and is economical and practical at the same time. Compared with some conventional non-invasive detection methods, the method provided by the invention has similar detection accuracy, but has the advantage that the method is not influenced by the weight and gender of a patient.

Description

technical field [0001] The invention belongs to the field of medical technology, and specifically relates to the application of N-terminal DDR1 polypeptide. Background technique [0002] Hepatic fibrosis is a series of dynamic pathophysiological processes characterized by hepatocyte degeneration and necrosis after chronic liver injury. The etiology includes hepatotoxic drug injury and cholestasis. Liver fibrosis is the most important predictor associated with morbidity and mortality in liver disease. Liver fibrosis is increasingly recognized as more than a single disease entity. Studies have shown that early liver fibrosis and even cirrhosis can be reversed. Furthermore, detection of advanced fibrosis and cirrhosis is critical to support treatment decisions, determine monitoring intervals, and predict clinical outcome. [0003] For decades, liver biopsy remained the gold standard for clinical assessment of liver fibrosis. Inherent defects of this procedure, such as sampl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/573
CPCG01N33/6893G01N33/573G01N2800/085G01N2333/91215
Inventor 张宇鑫张万广张占国朱敬涵熊逸潇蔡宁程坤
Owner TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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