Pre-surgical risk stratification based on pde4d7 expression and pre-surgical clinical variables

A technology for risk stratification and risk scoring, applied in the fields of biochemical equipment and methods, microbial determination/inspection, instruments, etc.

Pending Publication Date: 2020-10-02
KONINKLJIJKE PHILIPS NV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These patients suffer from subsequent treatment burdens often triggered by biochemical recurrence

Method used

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  • Pre-surgical risk stratification based on pde4d7 expression and pre-surgical clinical variables
  • Pre-surgical risk stratification based on pde4d7 expression and pre-surgical clinical variables
  • Pre-surgical risk stratification based on pde4d7 expression and pre-surgical clinical variables

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Experimental program
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Embodiment

[0121] Patient cohort and samples

[0122] Two patient cohorts were used, a radical prostatectomy (RP) patient cohort and a diagnostic biopsy (DB) patient cohort. The demographic data is shown in Table 2. For the RP patient cohort, a small drill biopsy (approximately 1 mm × 2 mm) was collected from a representative tumor area of ​​the resected prostate of 550 patients who were in a large German hospital between 2000 and 2004. Large-scale clinical centers have successively performed operations. After quality control of the study data based on pre-defined criteria and removal of patients receiving adjuvant hormone therapy, 503 patient samples were found to be eligible for statistical analysis. For the DB patient cohort, a drill biopsy sample (approximately 1 mm × 2 mm) was collected from the tumor-positive diagnostic biopsy with the highest Gleason score for each patient. In this case, 168 patients were diagnosed with prostate cancer and underwent surgery at University Klinik Mue...

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Abstract

The invention relates to a method of pre-surgical risk stratification of a prostate cancer subject, comprising determining a gene expression profile for phosphodiesterase 4D variant 7 (PDE4D7) in a biological sample obtained from the subject, determining an expression based risk score for the subject based on the gene expression profile, and determining a pre-surgical prognostic risk score for thesubject based on the expression based risk score and pre-surgical clinical variables of the subject. This may allow for an improved stratification of the subject in a pre-surgical setting that may result in better primary treatment decisions. For instance, the pre-surgical prognostic risk score may allow to make better recommendations on whether to select active surveillance vs. active intervention, e.g., radical prostatectomy, for certain sub-populations of prostate cancer patients.

Description

[0001] Invention field [0002] The present invention relates to a method for preoperative risk stratification of prostate cancer subjects. In addition, the present invention relates to a diagnostic kit, the application of the kit in a method for preoperative risk stratification of prostate cancer subjects, and the gene expression profile of phosphodiesterase 4D variant 7 (PDE4D7) in prostate cancer subjects. Application in preoperative risk stratification and related computer program products. [0003] Background of the invention [0004] Cancer is a type of disease in which a group of cells show uncontrolled growth, invasion and sometimes metastasis. These three malignant properties of cancer distinguish it from benign tumors, which are self-limiting and do not invade or metastasize. Prostate cancer (PCa) is the most common non-skin malignant tumor in men. Its manifestation is a heterogeneous disease with various potentials to gradually progress into a fatal form of the disease....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/112C12Q2600/118C12Q2600/158G16H50/30G16B25/10G16B40/00
Inventor R·D·霍夫曼
Owner KONINKLJIJKE PHILIPS NV
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