Automatic positioning method for critical heat production value of magnetic nanoparticles based on simplex algorithm

Abstract

The invention relates to an automatic positioning method for a critical heat production value of magnetic nanoparticles based on a simplex algorithm. After a simplex algorithm and a magnetic nanoparticle critical heat production technology are introduced, a finite element method is applied to solve the biological heat transfer mathematical model based on magnetic nanoparticle heat production, andthe magnetic nanoparticle critical heat production value is automatically positioned through algorithm optimization; on the basis, the application of the improved magnetic nanoparticle heat productiontheory effectively improves the prediction precision of the temperature distribution of the target geometric model. According to the invention, the optimal particle attribute of the magnetic nanoparticles during the magnetic hyperthermia period can be finally optimized so as to be applied to the magnetic nanometer hyperthermia instrument, and the magnetic hyperthermia effect of the magnetic nanometer hyperthermia instrument is improved.

Description

technical field [0001] The invention relates to the technical field of nanoparticle modeling, in particular to an automatic positioning method for the critical heat production value of magnetic nanoparticle based on a simplex algorithm. Background technique [0002] The heat generation mechanism of magnetic nanoparticles under alternating magnetic field has been widely used in various fields, including magnetic resonance imaging, non-contact temperature measurement, and magnetic nanothermotherapy. However, in practical applications, the heat generation of magnetic nanoparticles is difficult to control and determine due to the influence of various determinants. These determinants include the strength of the applied magnetic field, the frequency of the magnetic field, the particle size of the magnetic nanoparticles, the anisotropy constant of the nanoparticles, and other property parameters. Therefore, magnetic nanoparticles also have such common problems in the application o...

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Problems solved by technology

The main problem of this method is that it is impossible to obtain the ideal result more accurately and quickly, and at the same time, there will be obvious errors in the final results, which will eventually affect the effect of practical applications.

In the field of magnetic nanohyperthermia, existing inventions mainly focus on the preparation of magnetic nanoparticles and the research of drug carriers, and less involve the mechanism of heat production based on magnetic nanoparticles, the optimization of magnetic nanoparticle properties, and the analysis of temperature distribution.

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