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Application of artebenolide in eliminating quinolone residues in cultured fish

A technology of artebolide and quinolone, which is applied in the field of aquatic animal pharmacology, can solve the problems affecting consumers' health, aquatic product quality and safety, and quinolone drug residues, etc., so as to shorten the residual time, reduce risks, and reduce residual volume reduction effect

Active Publication Date: 2022-06-17
YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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Problems solved by technology

With the rapid development of my country's aquaculture industry, the output of my country's aquatic products ranks first in the world, but also with the frequent occurrence of bacterial diseases in various aquatic animals, quinolones are used in large quantities. On the one hand, the bacterial diseases of aquatic animals have been eliminated. Treatment, on the other hand, also caused the problem of quinolone drug residues in aquatic products, caused the quality and safety of aquatic products, and then affected the health of consumers

Method used

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  • Application of artebenolide in eliminating quinolone residues in cultured fish
  • Application of artebenolide in eliminating quinolone residues in cultured fish
  • Application of artebenolide in eliminating quinolone residues in cultured fish

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Embodiment Construction

[0015] Test fish: Channel catfish, with an average weight of (180±32) g, purchased from Baishazhou Market in Wuhan City, transported to the laboratory, and placed in an aquarium that has been cleaned and disinfected with potassium permanganate (122cm×80cm×80cm) The test water was fully aerated tap water. After the temporary support, individuals with no disease or injury and uniform specifications were selected for the test, and the water temperature was controlled at 24±1℃.

[0016] Sarafloxacin (purity ≥98.0%, purchased from Shanghai Yuanye Biotechnology Co., Ltd.), Artemisinolide (purity ≥98.0%, purchased from Shanghai Yuanye Biotechnology Co., Ltd.).

[0017] The experiment was divided into two groups, one group was the control group which was orally irrigated with sarafloxacin (oral dose of 20 mg / kg fish body weight), the control group was orally irrigated with sarafloxacin for 12 hours and then was irrigated with distilled water; the other group of channel catfish After ...

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Abstract

The invention discloses the application of artebenolide in eliminating the residues of quinolones (especially sarafloxacin) in cultured fish. On the one hand, artebolide can reduce the residual concentration of quinolones in cultured fish. On the one hand, artebolactone can significantly shorten the elimination half-life and drug withdrawal period of quinolones in cultured fish. Artebenolide can be used to accelerate the elimination of quinolone chemical drug residues in farmed fish, which is of great significance for ensuring the quality and safety of aquatic products and reducing the risk of human intake of aquatic products containing quinolone chemical drug residues.

Description

technical field [0001] The invention belongs to the technical field of aquatic animal pharmacology, in particular to the application of artesunolide in accelerating the elimination of quinolone drug (especially sarafloxacin) residues in cultured fish. Background technique [0002] Quinolones are a class of synthetic antibacterial drugs, which are widely used in the prevention and treatment of bacterial diseases in aquaculture animals due to their strong antibacterial activity, broad antibacterial spectrum and low price. With the rapid development of my country's aquaculture industry, my country's aquatic product output ranks first in the world, but with the frequent occurrence of various aquatic animal bacterial diseases, quinolones are widely used. Treatment, on the other hand, also caused the problem of quinolones residues in aquatic products, which led to the quality and safety of aquatic products, which in turn affected the health of consumers. In 2019, the Heilongjiang ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/74A01K61/10A23K50/80A23K20/121
CPCG01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/74A01K61/10A23K50/80A23K20/121G01N2030/324Y02A40/81
Inventor 刘永涛王桢月艾晓辉杨秋红董靖杨移斌周顺
Owner YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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