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Immunosuppressive leukocyte adsorption material and adsorption column

An adsorption material and immunosuppressive technology, which is applied in the fields of suction devices, blood circulation treatment, chemical instruments and methods, etc., can solve the problems of unsatisfactory therapeutic effect and overactive immune suppression system

Active Publication Date: 2020-06-12
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current situation is that the therapeutic effect of this therapy is not sufficiently satisfactory, and one of the reasons for this is presumed to be due to hyperactivity of the immune suppression system

Method used

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  • Immunosuppressive leukocyte adsorption material and adsorption column
  • Immunosuppressive leukocyte adsorption material and adsorption column

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0149] Diethylenetriamine (hereinafter referred to as DETA) (929 μL) and triethylamine (28.6 mL) were dissolved in dimethyl sulfoxide (398 mL), and stirred at room temperature for 1 hour in the resulting solution. Intermediate 1 (10 g) was impregnated under conditions of . Then, the intermediate 1 treated with diethylenetriamine was washed with water and dried to obtain an adsorbent E1.

Embodiment 2

[0151] Tetraethylenepentamine (hereinafter referred to as TEPA) (1640 μL) and triethylamine (28.6 mL) were dissolved in dimethyl sulfoxide (398 mL), and stirred at room temperature for 1 hour in the resulting solution. Intermediate 1 (10 g) was impregnated under conditions of . Then, the intermediate 1 treated with tetraethylenepentamine was washed with water and dried to obtain an adsorbent E2.

Embodiment 3

[0159] Except having made the immersion time into 10 minutes, the same process as Example 1 was performed, and the adsorbent E3 was obtained.

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Abstract

The purpose of the present invention is to provide an adsorption material capable of selectively adsorbing immunosuppressive leukocytes. The present disclosure provides an immunosuppressive leukocyteadsorption material containing a water-insoluble carrier to which is bonded one or more nitrogen-containing compounds selected from polyamines represented by a prescribed formula and aliphatic aminesrepresented by a prescribed formula, the water-insoluble carrier having the form of fibers or particles, the diameter of the fibers or the particles being 15-50 mum, and the arithmetic mean roughnessof the surface of the water-insoluble carrier being 0.1-3.0 mum.

Description

technical field [0001] The present disclosure relates to an adsorption material for immunosuppressive leukocytes and an adsorption column containing the same. Background technique [0002] It has gradually become clear that cancer is closely related to immunity, and in recent years, it has been reported that immunosuppressive blood components increase in many advanced cancers. [0003] White blood cells closely related to immune function are one of the blood components and are divided into lymphocytes, granulocytes, and monocytes. Various white blood cells are further subdivided, for example, lymphocytes are classified into T cells, B cells, natural killer cells, etc. [0004] In recent years, as one of the molecules involved in the progression of cancer, it has been gradually clarified that hyperactivation of immunosuppressive leukocytes, such as LAP-positive T cells, prevents cancer cells from the attack of the immune system and is involved in the progression of cancer. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36B01J20/26B01J20/28
CPCB01J20/28011A61M1/3679B01J20/3248B01J20/321B01J20/28023B01J20/28038B01J20/3219B01J20/28016B01J20/28004A61M1/362A61M1/3678B01J20/261A61M2202/0439A61M1/36B01J20/28002
Inventor 上野良之粕谷淳一荒金彻松长辽关谷由美子上田祐二寺本和雄小笠原一诚
Owner TORAY IND INC
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