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Application of Oxinaline in Antibacterial Drugs and Method for Screening Antibiotics

A technology of drugs and bacterial strains, applied in the field of medicine, can solve the problems of antibiotics losing their effectiveness, and achieve the effect of simple and easy operation steps, reduced cycle time, and easy control

Active Publication Date: 2021-04-06
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the abuse of antibiotics, a large number of drug-resistant pathogens are produced, and their rapid spread makes traditional antibiotics useless, and human health is facing a new crisis. These make the development of new antibacterial drugs imminent

Method used

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  • Application of Oxinaline in Antibacterial Drugs and Method for Screening Antibiotics
  • Application of Oxinaline in Antibacterial Drugs and Method for Screening Antibiotics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] This example provides an application of orcinalin, which has bactericidal, antibacterial or bacteriostatic activity, and the application of orcinalin in the preparation of bactericidal, antibacterial or bacteriostatic products.

Embodiment 2

[0056] This embodiment provides an application of orcinalin, which has bactericidal, antibacterial or bacteriostatic activity, and the application of orcinalin in the preparation of bactericidal, antibacterial or bacteriostatic products, and the product is a drug.

Embodiment 3

[0058] The present embodiment provides a kind of application of Ossinaline, Ossinaline has bactericidal, antibacterial or bacteriostatic activity, and the application of Ossinaline in the preparation of bactericidal, antibacterial or bacteriostatic drug, described medicine is that Ossinaline is used as The bactericidal, antibacterial or bacteriostatic active ingredients are prepared into any pharmaceutically acceptable preparation.

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PUM

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Abstract

The invention relates to an application of orcinalin, which has bactericidal, antibacterial or bacteriostatic activity, and the application of orcinarin in the preparation of bactericidal, antibacterial or bacteriostatic products. The method for screening antibacterial drugs comprises constructing menA-deficient bacterial strains; transforming plasmids containing menA into defective bacterial strains; performing drug screening to obtain antibacterial drugs. Beneficial effects of the present invention: for the first time, a menA-deficient strain was prepared, and it was attempted to design and screen drugs based on this; it was found that it had a specific inhibitory effect on MenA, an important enzyme in the bacterial respiratory chain, which indicated that Oxibalin has potential antibacterial effect; it belongs to the new use of old drugs, which greatly reduces the cycle of drug development.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an application of orcinalin in antibacterial drugs and a method for screening antibacterial drugs. Background technique [0002] Antibiotics are a powerful weapon for human beings to fight against bacterial infectious diseases. They have saved countless lives during their 70 years of clinical application. Commonly used antibiotics include β-lactam antibiotics, quinolone antibiotics, aminoglycoside antibiotics, and macrocyclic antibiotics. Lactones etc. However, with the abuse of antibiotics, a large number of drug-resistant pathogens are produced, and their rapid spread makes traditional antibiotics useless, and human health is facing a new crisis, which makes the development of new antibacterial drugs imminent. [0003] In view of this, apply for this patent. Contents of the invention [0004] In order to solve the problems existing in the prior art, the present...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/137A61P31/04C12N15/70C12Q1/18C12R1/19
CPCA61K31/137A61P31/04C12N15/70C12Q1/18G01N2333/245
Inventor 程伟陈斌
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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