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Establishment method of CXCR4 targeted drug treatment triple negative breast cancer platform

A technique for triple-negative breast cancer and the establishment of a method, which is applied in the establishment of a platform for CXCR4-targeted drug treatment of triple-negative breast cancer, which can solve the problem of not explaining the relationship between breast cancer and other issues

Pending Publication Date: 2020-03-31
SHANTOU UNIV MEDICAL COLLEGE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In summary, the problem with the prior art is that CXC chemokine receptor type 4 (CXCR4) plays an important role in cancer progression and metastasis
The prior art does not address the association of CXC chemokine receptor type 4 with breast cancer subtypes

Method used

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  • Establishment method of CXCR4 targeted drug treatment triple negative breast cancer platform
  • Establishment method of CXCR4 targeted drug treatment triple negative breast cancer platform
  • Establishment method of CXCR4 targeted drug treatment triple negative breast cancer platform

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Embodiment Construction

[0029] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0030] The application principle of the present invention will be further described below in conjunction with the accompanying drawings.

[0031] Such as figure 1 As shown, the establishment method of the CXCR4 targeted drug treatment platform for triple-negative breast cancer provided by the embodiments of the present invention includes the following steps:

[0032] S101: Select 75 consecutive TNBC, 41 consecutive luminal breast cancers and 60 consecutive HER2-positive breast cancers; then monitor;

[0033] S102: Analyze by immunohistochemistry and statistics.

[0034] In a preferred embodiment of the present invention,...

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Abstract

The invention belongs to the technical field of information data processing, and discloses an establishment method of a CXCR4 targeted drug treatment triple negative breast cancer platform, which analyzes the expression level and cell position of CXCR4 in breast tumor, including triple negative breast cancer, lumen subtype and HER2 positive breast cancer by immunohistochemistry. It is found that the expression frequency of CXCR4 in TNBCs is higher than that of CXCR4 in other subtypes; in a TNBC group, the visceral transfer rate of a CXCR4 positive patient is obviously high; the expression level of the CXCR4 is also obviously related to the tumor size, the advanced TNM staging, the shorter overall body and the disease-free survival rate; and in a lumen or HER2 positive breast cancer group,CXCR4 is independent of such clinical pathological features and survival rates. The data shows that the CXCR4 can only play a role in a TNBC patient, and shows that the targeted CXCR4 can be an effective therapy for the TNBC patient.

Description

technical field [0001] The invention belongs to the technical field of information data processing, and in particular relates to a method for establishing a CXCR4-targeted drug treatment platform for triple-negative breast cancer. Background technique [0002] A recently developed microarray approach enables the molecular classification of breast cancer into four distinct subtypes, namely luminal, HER2-overexpressing, normal-like and basal-like subtypes. Different subtypes exhibit diverse behaviors, such as clinical outcomes and responses to treatment. However, genetic profiling is not practical for routine diagnosis due to cost and high demand for specialized facilities. Therefore, alternative immunohistochemical markers were used instead to obtain a similar classification. Thus, breast cancers are classified as luminal when tumors express estrogen receptor (ER) and / or progesterone receptor (PR), with or without HER2 overexpression, and when tumors are ER and / or PR negati...

Claims

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Application Information

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IPC IPC(8): G01N33/574
CPCG01N33/57415G01N33/57484G01N2333/7158
Inventor 杜彩文黄伯彦王薇薇吴南强
Owner SHANTOU UNIV MEDICAL COLLEGE
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