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A kind of preparation method and application of Rhodiola rosea fermentation extract

An extract, Rhodiola rosea technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of insufficient release of active substances, no supplementary nutrients, and no hyaluronidase activity. and research on anti-inflammatory effects to achieve the effect of improving fermentation efficiency and shortening fermentation cycle

Active Publication Date: 2022-07-12
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 1. Rhodiola is mostly fermented with other raw materials, so the stability of the product is difficult to guarantee, and the advantages of anti-oxidation and whitening effects of Rhodiola cannot be highlighted
[0009] 2. The Rhodiola rosea extract after heating, extraction and filtration is often used as the fermentation culture medium. The active substances in the Rhodiola rosea slag may not be fully released into the liquid, and other nutrients are not supplemented. During the fermentation process, the bacteria may Consume the Active Ingredients in Rhodiola
[0010] 3. There is no research on the inhibition of hyaluronidase activity and anti-inflammatory effect of rhodiola

Method used

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  • A kind of preparation method and application of Rhodiola rosea fermentation extract
  • A kind of preparation method and application of Rhodiola rosea fermentation extract
  • A kind of preparation method and application of Rhodiola rosea fermentation extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Take 1.1 kg of dried Rhodiola rosea root as a raw material, fully pulverize it by a milling pulverizer, then pass through a 60-mesh sieve, and sieve Rhodiola root powder for use. Weigh about 1kg of Rhodiola rosea root powder under the sieve, mix it in 50L drinking water, adjust the pH to 3.0, add 10mL of cellulase, keep at 40℃, measure the change of glucose content every 0.5h, and it will not change after 3h. Adjust pH to 2.5, add 100 mL of pectinase, keep at 60°C, measure the change of glucose content every 0.5h, no change after 1.0h, then heat up to 100°C, hold for 10min to kill the enzyme, and then add 3.75kg of maltitol , 1.25kg peptone, 0.125kg K 2 HPO 4 , add tap water to 125L and mix well and use it as a fermentation culture medium. After sterilization, when cooled to 25°C, add 125ml of Saccharomyces cerevisiae seed solution, cultivate at 25°C for 35h, and end the fermentation when there is no residual sugar. Centrifuge at 8000 rpm to remove impurities, and the...

Embodiment 2

[0096] Take 1.4kg of dried Rhodiola rosea root as a raw material, and after fully pulverizing by a milling pulverizer, pass through a 100-mesh sieve, and sieve Rhodiola rosea root powder for use. Weigh about 1kg of Rhodiola rosea root powder under the sieve, mix it in 50L drinking water, adjust the pH to 6.0, add 100mL of cellulase, keep at 60℃, measure the change of glucose content every 0.5h, and it will not change after 1h. Adjust the pH to 4.5, add 10 mL of pectinase, keep at 40 °C, measure the change of glucose content every 0.5 h, no change after 3.0 h, then heat up to 100 °C, hold for 10 min to kill the enzyme, and then add 15 kg of glycerol, 15 kg of wheat Peptone, 0.5kg CaCl 2 , add tap water to 500L, mix well and use it as a fermentation medium. After sterilization, when cooled to 25°C, add 500ml of Saccharomyces cerevisiae seed liquid, cultivate at 25°C for 40 hours, and end the fermentation after no residual sugar. Centrifuge at 8000 rpm to remove impurities, and ...

Embodiment 3

[0098] Take 1.1 kg of dried Rhodiola rosea root as a raw material, fully pulverize it by a milling pulverizer, then pass through a 60-mesh sieve, and sieve Rhodiola root powder for use. Weigh about 1kg of Rhodiola rosea root powder under the sieve, mix it in 50L drinking water, adjust the pH to 3.5, add 15mL of cellulase, keep at 40℃, measure the change of glucose content every 0.5h, and it will not change after 3h. Adjust the pH to 4.5, add 15 mL of pectinase, keep at 42°C, measure the change of glucose content every 0.5h, and no change after 3.0h, then heat up to 100°C, hold for 10min to kill the enzyme, then add 3.5kg of glucose, 3.5 kg peptone, 1.75kg K 2 HPO 4 , add tap water to 350L, mix well and use it as a fermentation medium, sterilize and cool to 25°C, add 2.8L of Saccharomyces cerevisiae seed solution, cultivate at 25°C for 20 hours, and end the fermentation when there is no residual sugar. Centrifuge at 8000 rpm to remove impurities, and then filter and sterilize...

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Abstract

The invention discloses a preparation method of Rhodiola rosea fermented extract. Then add enzyme for enzymolysis, enzymolysis to the end point, and then heat up to kill the enzyme to obtain Rhodiola root powder enzymolysis solution; inoculate the yeast seed liquid into the fermentation culture solution with Rhodiola root powder enzymolysis solution, and carry out Fermentation, after the fermentation is completed, a fermentation liquid is obtained; the fermentation liquid is removed from impurities and bacteria to obtain the Rhodiola rosea fermentation extract. The invention also relates to the application of a Rhodiola rosea fermentation extract. The preparation method of the Rhodiola fermented extract of the present invention uses Rhodiola root powder as the main raw material, first enzymatically hydrolyzed, then inoculated with yeast for fermentation, centrifuged and filtered to obtain the Rhodiola fermented extract. The Rhodiola rosea fermented extract prepared by the method provided by the invention has good whitening and lightening, anti-oxidative and anti-inflammatory effects.

Description

technical field [0001] The present application relates to the field of cosmetic raw materials, and more particularly to a preparation method and application of a Rhodiola rosea fermentation extract. Background technique [0002] Rhodiola rosea is a rare wild plant that grows in alpine and pollution-free areas. It is a traditional medicine for the Tibetan people in my country. It has been used for more than 1,000 years. It has the functions of stimulating the nervous system, increasing work efficiency, eliminating fatigue and preventing altitude sickness. In addition, Rhodiola also has the functions of protecting cardiovascular and cerebrovascular, nerve cells, and anti-tumor and anti-radiation. Because it contains flavonoids, amino acids, polyphenols and other biologically active ingredients, Rhodiola also has anti-inflammatory, antioxidant, anti-aging, whitening and other cosmetic effects. [0003] So far, there are many studies on fermented Rhodiola, such as Chinese paten...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61Q19/00A61Q19/08A61Q19/02A61K36/41A61P29/00
CPCA61K8/9789A61Q19/00A61Q19/08A61Q19/02A61K36/41A61P29/00A61K2800/782A61K2800/85A61K2236/19
Inventor 魏玉洁陆震陈玉娟李芬王成山孙元军石艳丽郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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