Short chain polypeptide capable of promoting TFEB nuclear translocation, linear short chain polypeptide based on short chain polypeptide, and application of short chain polypeptide to alleviating cerebral ischemia damage

A short peptide and linear technology, applied in the field of short peptides that promote TFEB nuclear translocation, linear short peptides and their reduction in cerebral ischemic damage, can solve the problems of no research reports, etc., to reduce cell death, increase expression, increase wear Effect of Membrane Efficiency

Active Publication Date: 2020-01-24
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

Whether regulating CMA is the key to alleviating cerebral ischemic injury, and whether TFEB, a key regulator of the autophagy-lysosome pat

Method used

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  • Short chain polypeptide capable of promoting TFEB nuclear translocation, linear short chain polypeptide based on short chain polypeptide, and application of short chain polypeptide to alleviating cerebral ischemia damage
  • Short chain polypeptide capable of promoting TFEB nuclear translocation, linear short chain polypeptide based on short chain polypeptide, and application of short chain polypeptide to alleviating cerebral ischemia damage
  • Short chain polypeptide capable of promoting TFEB nuclear translocation, linear short chain polypeptide based on short chain polypeptide, and application of short chain polypeptide to alleviating cerebral ischemia damage

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Embodiment Construction

[0031] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0032] It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate ...

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Abstract

The invention discloses short chain polypeptide capable of promoting TFEB nuclear translocation, linear short chain polypeptide based on the short chain polypeptide, and an application of the short chain polypeptide to alleviating cerebral ischemia damage, and belongs to the technical field of biological pharmaceuticals. The short chain polypeptide disclosed by the invention is short chain polypeptide obtained through fusing function areas combined from TFEB protein and 14-3-3 protein, and the nucleotide sequence is as shown in SEQ.ID.NO.1. The invention further discloses the linear short chain polypeptide protecting the short chain polypeptide. The linear short chain polypeptide is obtained through fusing cell-penetrating peptide with the short chain polypeptide. Experiment verifies thatthe synthesized peptide can adjust and control TFEB nuclear translocation, and promote CMA to alleviate cell injury. Therefore, the invention discloses an application of the short chain polypeptide totreatment new target points for alleviating nerve cell death and improving cerebral ischemia damage.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a short peptide that promotes TFEB nuclear translocation, enhances chaperone-mediated autophagy (CMA) and relieves nerve damage and its application, and specifically relates to a method for promoting TFEB nuclear translocation Short peptides and linear short peptides based on them and their application in alleviating cerebral ischemic injury. Background technique [0002] Stroke is a serious threat to human life and health. There are approximately 16.9 million new stroke patients worldwide each year, and 5.9 million patients die of stroke-related diseases; another 33 million stroke patients need long-term treatment and care, which brings heavy burdens to society and families. Burden (Lancet, 2017). tPA (Tissue plasminogen activator) is currently the only drug approved by the US FDA for the treatment of ischemic stroke, but its treatment time window is short and increases the r...

Claims

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Application Information

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IPC IPC(8): C07K19/00A61K38/08A61K47/64A61P9/10A61P25/00
CPCA61K38/00A61P9/10A61P25/00C07K7/06C07K2319/10
Inventor 方宗平冯云侯武刚张西京熊利泽董海龙苏斌虓李雨衡王佳佳王世全王进邓姣杨博左文强
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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