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Application of specific lectin in preparation of test tool for identifying lung cancer and device

A lectin and a specific technology, applied in the field of lung cancer identification, can solve the problems of high false positive rate, low detection rate, unsatisfactory application effect, etc., achieve high organ specificity and reduce test cost

Pending Publication Date: 2020-01-17
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the methods used in clinical diagnosis of lung cancer mainly include imaging, cytopathology and serological index examination. The actual clinical application effect is not ideal, especially the early diagnosis value is limited

Method used

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  • Application of specific lectin in preparation of test tool for identifying lung cancer and device
  • Application of specific lectin in preparation of test tool for identifying lung cancer and device
  • Application of specific lectin in preparation of test tool for identifying lung cancer and device

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Embodiment Construction

[0031] The relevant verification experiments and analysis of the present application are introduced below, and the inventor's specific research and development process is not limited thereto; the specific examples given are not intended to limit the present application.

[0032] The present application screens lectin probes for identifying lung cancer patients from 37 lectins (as shown in Table 1).

[0033] Table 1 Names of 37 lectins

[0034]

[0035]

[0036]The reagent materials mainly used in this application are shown in Table 2, and the rest of the commonly used reagents are of domestic analytical grade; the instruments and equipment are shown in Table 3, and the rest of the commonly used instruments and equipment are all made in China.

[0037] Table 2 Reagents and materials used in experiments

[0038]

[0039] Table 3 Instruments and equipment used in the experiment

[0040]

[0041] 1. Study population and collection of bronchoalveolar lavage fluid

[...

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Abstract

The invention provides an application of specific lectin in preparation of a test tool for identifying lung cancer and a device. For a sample taken from bronchoalveolar lavage fluid, the specific lectin is any one or any combination of the following lectins: MAL-II, RCA120, ECA, HHL, GSL-I, DBA, DSA and AAL. When a sugar chain structure identified by the lectins MAL-II, RCA 120, ECA, and HHL is significantly increased and a sugar chain structure identified by the lectins GSL-I, DBA, DSA, and AAL is significantly reduced, the sample comes from a patient with benign pulmonary disease (BPD), otherwise the sample comes from a lung cancer patient as determined. According to the invention, the bronchoalveolar lavage fluid is used as a test sample. Since the sample is directly obtained from a primary lesion adjacent to tumor cells, it has high organ specificity and can directly reflect true condition of the patient. The test tool of the invention is safe and minimally invasive.

Description

technical field [0001] The present application relates to a technology for identifying lung cancer based on glycoprotein glycoforms, and specifically relates to the use of specific lectins in making test tools and corresponding devices. Background technique [0002] Lung cancer is one of the most common malignant tumors, which seriously endangers human health. Its morbidity and lethality rank first among all malignant tumors. The reports "Global Cancer Statistics 2018" and "Cancer Incidence and Mortality in China in 2014" show that the incidence and mortality of lung cancer account for 11.6% and 18.4% (global), 20% and 27.3% of the total cancer population. %(China). [0003] Lung cancer can generally be divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (Small cell lung cancer, SCLC). According to different pathological features, NSCLC mainly includes lung adenocarcinoma (Adenocarcinoma, ADC) and lung squamous carcinoma (Squamous carcinoma, SCC). T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/535G01N33/533G01N21/64G01N33/574
CPCG01N21/6428G01N33/533G01N33/535G01N33/57423G01N33/57484G01N2021/6439
Inventor 陈明伟刘丽娜郭炫李铮陈天君张宸
Owner XIAN MEDICAL UNIV
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