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Long-acting adrenomedullin derivative

A technology of adrenomedullin and compounds, applied in the field of long-acting adrenomedullin derivatives, can solve problems such as short half-life

Pending Publication Date: 2020-01-10
UNIVERSITY OF MIYAZAKI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Peptides are generally known to have a short half-life in vivo due to metabolic reactions in the body (e.g. blood)

Method used

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  • Long-acting adrenomedullin derivative
  • Long-acting adrenomedullin derivative
  • Long-acting adrenomedullin derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0278] Example 1: (IgG1 Fc region) + (connecting peptide S) + (AM-Gly); (SEQ ID NO:14, SEQ ID NO:15)

Embodiment 2

[0279] Example 2: (IgG1 Fc region) + (connecting peptide K) + (AM-Gly); (SEQ ID NO: 16, SEQ ID NO: 17)

Embodiment 3

[0280] Example 3: (IgG4 Fc region) + (connecting peptide S) + (AM-Gly); (SEQ ID NO: 18, SEQ ID NO: 19)

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PUM

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Abstract

Provided is a novel long-lasting adrenomedullin derivative that is capable of substantially inhibiting an undesired side reaction while maintaining the pharmacological effect of adrenomedullin. One embodiment of the present invention pertains to a compound represented by formula (I): A-L-B, wherein A represents the Fc region of immunoglobulin; B represents a peptide fragment derived from adrenomedullin or a modification thereof having the adrenomedullin activity; and L represents a linking group comprising a peptide having an arbitrary amino acid sequence, a salt thereof or a hydrate of the same. Another embodiment of the present invention pertains to a method for producing a compound represented by formula (I) and a drug comprising the compound as an active ingredient.

Description

Technical field [0001] The present invention relates to a long-acting adrenomedullin derivative. Background technique [0002] Adrenomedullin (also described as "AM" hereinafter) is a biologically active peptide isolated and identified from pheochromocytoma tissue in 1993 (Non-Patent Document 1). At the beginning of the discovery, it has been confirmed that AM can exert a strong antihypertensive effect of expanding blood vessels. For example, Patent Document 1 describes a peptide containing a human AM amino acid sequence that has a blood pressure lowering effect. [0003] Subsequent studies have shown that AM can play a variety of pharmacological effects such as cardiovascular protection, anti-inflammatory effects, angiogenesis and promoting tissue repair. In addition, in order to apply the pharmacological effects of AM in the treatment of diseases, studies on the administration of AM have been conducted for patients with various diseases. Among them, AM is expected to be useful...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/12A61K38/10A61K47/68A61P9/00A61P29/00C07K14/47C07K19/00C12N15/62C12P21/02
CPCA61K38/10A61K47/68C12N15/62C12P21/02C07K2319/30C07K14/575A61P9/08A61K38/00
Inventor 北村和雄山崎基生永田鞘香
Owner UNIVERSITY OF MIYAZAKI
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