A method for constructing memory impairment model, anxiety model and aggressive aggressive mouse model at the same time

A construction method and memory-impaired technology, applied in animal husbandry and other directions, can solve problems such as non-compliance with changing trends

Active Publication Date: 2022-02-15
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The existing method of establishing a mouse model of mental illness is mainly to establish a mouse model through drug injection. After injecting the drug, the expression of the mouse molecular level will also be affected. In this way, when we study the influence of other factors on mental illness, Due to the influence of drugs, some molecular level changes may not follow the original trend

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  • A method for constructing memory impairment model, anxiety model and aggressive aggressive mouse model at the same time
  • A method for constructing memory impairment model, anxiety model and aggressive aggressive mouse model at the same time
  • A method for constructing memory impairment model, anxiety model and aggressive aggressive mouse model at the same time

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Embodiment 1

[0025] This embodiment is a method for simultaneously constructing a memory impairment model, an anxiety model and a strong aggressive mouse model of the present invention, comprising the following steps:

[0026] (1) Acclimatization: Three groups (12 in each group) of six-week-old mice in puberty were randomly placed in a temperature of 28 ° C, a humidity of 50%, light (8:00 in the morning to 8:00 in the evening) and night ( 8:00 p.m. to 8:00 a.m.) respectively in the same cage for 12 hours to domesticate separately for one week, during the domestication process, the mice were free to eat the same feed and water;

[0027] (2) The three groups of mice domesticated in step (1) for one week were continuously stimulated for three weeks, 10 hours a day, the first group of mice were given heavy metal music (Anthrax band Madhouse) stimulation with a music decibel of 65 decibels, the second group of mice Give music decibel to be the light music (Mozart's lullaby) stimulation of 65 de...

Embodiment 2

[0031] This embodiment is a method for simultaneously constructing a memory impairment model, an anxiety model and a strong aggressive mouse model of the present invention, comprising the following steps:

[0032] (1) Domestication: Three groups of six-week-old mice in puberty were randomly placed in a temperature of 28°C, a humidity of 50%, light (8:00 in the morning to 8:00 in the evening) and night (from 8:00 in the evening to morning) 8:00) in the same cage for each 12h to domesticate separately for one week, and the mice were allowed to eat the same feed and drink freely during the domestication process;

[0033] (2) The three groups of mice domesticated in step (1) for one week were continuously stimulated for three weeks, 10 hours a day, the first group of mice were given heavy metal music (Anthrax band Madhouse) stimulation with a music decibel of 75 decibels, the second group of mice Give music decibel to be the light music (Mozart's lullaby) stimulation of 75 decibel...

Embodiment 3

[0037] This embodiment is a method for simultaneously constructing a memory impairment model, an anxiety model and a strong aggressive mouse model of the present invention, comprising the following steps:

[0038] (1) Domestication: Three groups of six-week-old mice in puberty were randomly placed in a temperature of 28°C, a humidity of 50%, light (8:00 in the morning to 8:00 in the evening) and night (from 8:00 in the evening to morning) 8:00) in the same cage for each 12h to domesticate separately for one week, and the mice were allowed to eat the same feed and drink freely during the domestication process;

[0039](2) The three groups of mice domesticated in step (1) for one week were continuously stimulated for three weeks, 10 hours a day, the first group of mice were given heavy metal music (Anthrax band Madhouse) stimulation with a music decibel of 70 decibels, the second group of mice Give music decibel to be the light music (Mozart's lullaby) stimulation of 70 decibels...

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Abstract

The invention relates to a method for simultaneously constructing a memory impairment model, an anxiety model and a strong aggressive mouse model, and belongs to the technical field of medical evaluation and detection. The construction method of simultaneously constructing memory impairment model, anxiety model and strong aggressive mouse model of the present invention, through different music stimuli, mice of different groups are placed in the blank control of heavy metal music, light music and no music; Under the stimulation of different music for 10 hours a day for three consecutive weeks, a mouse model of impaired memory, a mouse model of anxiety and a mouse model of aggressiveness were successfully established. In the mouse model construction method provided by the present invention, the mice are protected humanely, and the mice are not injected with drugs, which avoids the influence of other factors on the drugs for mental diseases in the study, and avoids some molecular level differences. Changes may not coincide with the occurrence of original trends in mental illness.

Description

technical field [0001] The invention relates to a method for simultaneously constructing a memory impairment model, an anxiety model and a strong aggressive mouse model, and belongs to the technical field of medical evaluation and detection. Background technique [0002] In the mouse modeling methods, there are different methods to establish different mouse models, including mouse depression modeling methods, mouse autism modeling methods, acute lymphoblastic leukemia mouse modeling methods, primary Liver cancer mouse modeling method, mouse anxiety model establishment and other methods. Among them, the commonly used method is to establish a mouse model by drug injection, and of course, there is also a method of modeling by blowing a mouse. Since the establishment of these modeling methods, they have helped us complete many exploratory experiments in scientific research, and also laid the foundation for us to explore other modeling methods. More importantly, exploring new m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K67/02
CPCA01K67/02
Inventor 杨新平冯涛迟雅丽杨小雪刘海华
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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