Method for quantifying tumor immune state based on radiomics

Abstract

The invention discloses a method for quantifying a tumor immune state based on radiomics, wherein the method comprises the following steps: S1, collecting clinical information, immunohistochemical characteristics, overall survival OS and disease-free survival DFS of tumor patients; S2, obtaining a CT image sample group of solid tumors; S3, randomly dividing the patients into a training set and a test set in proportion; S4, calculating the immunoscore by an immune marker, and dividing the patients into a set with high immune state and a set with low immune state; S5, segmenting an interest region, and extracting radiomics characteristics of the solid tumors in the interest region; S6, screening the radiomics characteristics related to the immune state from the radiomics characteristics in the training set, and training a prediction model; and S7, predicting the image immunoscore of the tumor patients, obtaining the image immune state, and then predicting the DFS and the OS in the patients. The immune state of the solid tumors such as colorectal cancer, lung cancer, gastric cancer and breast cancer is predicted by the CT image characteristics, and the analysis of pathological sections and immunohistochemistry is reduced or avoided.

Description

technical field [0001] The invention belongs to the technical field of image processing, and in particular relates to a method for quantifying tumor immune status based on radiomics. Background technique [0002] Currently, biopsy of pathological specimens of tumor patients, pathological staging, and then guiding clinical treatment are commonly used clinical detection methods. However, even though some patients have the same TNM stage and histological type, they have different prognosis, and many patients have advanced tumors when they are found and cannot be surgically removed, that is, pathological specimens cannot be obtained. Therefore, there is an urgent need for a simpler, faster and more accurate method to make up for the deficiency of TNM staging. [0003] Preoperative CT scanning is one of the routine preoperative examination items for patients, and it is applicable to a wide range of people and the examination time is short. Moreover, CT images contain a lot of i...

AI Technical Summary

Problems solved by technology

However, even though some patients have the same TNM stage and histological type, they have different prognoses, and many patients have advanced tumors that cannot be surgically removed, that is, pathological specimens cannot be obtained.

Images