A method for increasing chemical potency in antibiotic production

Abstract

The invention discloses a method for increasing chemical potency in antibiotic production. Through machine learning, it provides a safe, convenient and reasonable optimal operation plan aimed at improving the overall chemical potency, including: S10: Establish production Guidance model; the production guidance model includes event elements, time-period event chains, full-cycle event chains, and event chain graphs; S20: Learn the non-fixed elements and production operation plans corresponding to each time-period event chain in the event chain graph; S30: Generate chemical titers Distribution frequency table; record the frequency of occurrence of event chains in the same period and the chemical titer each time, and calculate the average chemical titer of event chains in this type of time period; S40: Determine the fixed elements of this fermentation and the event chains of the previous period and their non-volatile elements. For fixed elements, match the event chain of the same time period as this fermentation in the event chain map, and take the non-fixed elements and production operation plan of the time period event chain with the highest average chemical titer as the production guidance plan for this fermentation.

Description

technical field [0001] The invention relates to the technical field of production management, in particular to a method for increasing chemical potency in antibiotic production. Background technique [0002] Chemical potency refers to the potency of antibiotics determined by chemical methods in the production of antibiotics. It represents the total content of the drug and is a measure of the active ingredients of the drug. It has a high specificity for antibiotics whose chemical structure has been determined. , and its improvement is conducive to increasing the output of the product. [0003] The stable improvement of chemical potency is an important topic of general concern in the biopharmaceutical industry. The main difficulty lies in the fact that there are too many factors affecting the growth of microorganisms, there are many unknown or uncertain factors, and the potency is highly unpredictable. At present, the microbial fermentation stage in the field of biopharmaceut...

AI Technical Summary

Problems solved by technology

[0003] The stable improvement of chemical potency is an important topic of general concern in the biopharmaceutical industry. The main difficulty lies in the fact that there are too many factors affecting the growth of microorganisms, and there are many unknown or uncertain factors, and the potency is highly unpredictable.

At present, the microbial fermentation stage in the field of biopharmaceuticals is basically operated according to manual experience. Due to the many uncertainties in microbial growth, the chemical potency cannot be effectively controlled, which seriously restricts the ability to control production and cost.