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A kind of biomedical antibacterial agent with hydrophobicity

A biomedical and antibacterial agent technology, applied in the field of biomedical antibacterial, can solve the problems of affecting antibacterial performance and sustained release performance, affecting the uniformity of antibacterial agents, poor compatibility, etc., achieving low price, strong chemical stability, Good effect of lipophilicity

Active Publication Date: 2021-04-13
山西大医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A new type of inorganic antibacterial agent - graphene quantum dot coated nano-silver antibacterial agent has poor compatibility with silicone rubber, which affects the uniformity of antibacterial agent in silicone rubber, thereby affecting its antibacterial performance and sustained release performance
In response to the above problems, this patent selects an organosilicon monomer methyltriethoxysilane with a structure similar to that of a silicone rubber monomer as a modifier to hydrophobically modify the graphene quantum dot-coated nano-silver antibacterial agent , so that the antibacterial agent is evenly distributed in the silicone rubber, realize the compatibility and dispersion of the antibacterial agent in the silicone rubber, improve its antibacterial and slow-release properties, and solve the problem of graphene quantum dot-coated nano-silver antibacterial agent and biomedical silicon The defect of poor rubber compatibility can achieve high-efficiency antibacterial and reduce the occurrence of infection

Method used

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  • A kind of biomedical antibacterial agent with hydrophobicity
  • A kind of biomedical antibacterial agent with hydrophobicity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 1g of organosilicon monomer methyltriethoxysilane, add it into a 50ml beaker, then add 10ml of absolute ethanol, sonicate at room temperature for 30min, and stir in a water bath at room temperature for 10min to obtain the organosilicon monomer Alcoholic solution.

[0023] Weigh 5g of graphene quantum dots coated nano-silver antibacterial agent and place it in a 50ml beaker, add 10ml of distilled water, and ultrasonicate for 30min to obtain a dispersion of graphene quantum dots-coated nano-silver antibacterial agent.

[0024] The solution of organosilicon monomer is slowly added to the graphene quantum dot-coated nano-silver antibacterial agent dispersion, stirred at room temperature for 90 minutes, washed, dried, and filtered to obtain a hydrophobic alkylated graphene quantum-dot-coated nano-silver antibacterial agent.

Embodiment 2

[0026] Weigh 2g of organosilicon monomer methyltriethoxysilane, add it into a 50ml beaker, then add 20ml of absolute ethanol, ultrasonicate at room temperature for 30min, stir in a water bath at room temperature for 10min, and obtain the organosilicon monomer Alcoholic solution.

[0027] Weigh and place 4g of graphene quantum dot-coated nano-silver antibacterial agent in a 50ml beaker, add 10ml of distilled water, and ultrasonicate for 30min to obtain a dispersion of graphene quantum-dot-coated nano-silver antibacterial agent.

[0028] The solution of organosilicon monomer is slowly added to the graphene quantum dot-coated nano-silver antibacterial agent dispersion, stirred at room temperature for 90 minutes, washed, dried, and filtered to obtain a hydrophobic alkylated graphene quantum-dot-coated nano-silver antibacterial agent.

Embodiment 3

[0030] Weigh 3g of organosilicon monomer methyltriethoxysilane, add it into a 50ml beaker, then add 30ml of absolute ethanol, ultrasonicate at room temperature for 30min, stir in a water bath at room temperature for 10min, and obtain the organosilicon monomer Alcoholic solution.

[0031] Weigh 3g of the graphene quantum dot-coated nano-silver antibacterial agent and place it in a 50ml beaker, add 10ml of distilled water, and ultrasonicate for 30min to obtain a dispersion of the graphene quantum-dot-coated nano-silver antibacterial agent.

[0032] The solution of organosilicon monomer is slowly added to the graphene quantum dot-coated nano-silver antibacterial agent dispersion, stirred at room temperature for 90 minutes, washed, dried, and filtered to obtain a hydrophobic alkylated graphene quantum-dot-coated nano-silver antibacterial agent.

[0033] figure 1 In the above, when no antibacterial agent was added, colonies of E. coli (black) almost covered the entire medium, indi...

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Abstract

The invention relates to the field of biomedical antibacterial. A hydrophobic biomedical antibacterial agent, by weight, add 1-3 parts of organosilicon monomer into a 50ml beaker, and add 10 parts of solvent, ultrasonic for 30 minutes and stir for 10 minutes; 5 parts of graphene quantum dots are coated The nano-silver antibacterial agent was placed in a 50ml beaker, and 10 solvent was added, and ultrasonicated for 30 minutes; the solution of the organosilicon monomer was added to the prepared graphene quantum dot-coated nano-silver antibacterial agent dispersion, and stirred for 90 minutes; the prepared hydrophobic The silanized graphene quantum dot-coated nano-silver antibacterial agent dispersion is cooled at room temperature and dried to obtain a biomedical antibacterial agent with good antibacterial and hydrophobic properties.

Description

technical field [0001] The invention relates to the field of biomedical antibacterial. Background technique [0002] With the progress of society and the development of medicine, catheters have been widely used in the medical field. A common problem faced by various catheters in use is that infection is prone to occur in the implanted body, and the infection caused by long-term indwelling catheters is particularly serious. This kind of infection, on the one hand, prolongs the recovery time of patients and increases the chance of complications, on the other hand, it also causes an increase in medical expenses and a waste of medical resources. In order to avoid the occurrence of various infections and reduce the cost of patients, it is necessary to solve this problem from the source, that is, to endow the catheter itself with durable and excellent antibacterial properties to reduce the occurrence of infection. [0003] The traditional antibacterial catheter processing techno...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08K9/06C08K9/10C08K3/08C08K3/015C08L83/04
CPCC08K3/08C08K9/06C08K9/10C08K2003/0806C08K2201/003C08K2201/011C08K3/015C08L83/04
Inventor 张利王洁牛梅杨永珍张雁钢张超张姝
Owner 山西大医院
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