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A screening method for multiple myeloma prognostic genes

A multiple myeloma and gene technology, applied in the direction of instruments, data visualization, hybridization, etc., can solve the problem of not establishing a multiple myeloma prognosis gene screening method

Active Publication Date: 2022-02-01
THE FIRST AFFILIATED HOSPITAL OF FUJIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, the heterogeneity of multiple myeloma has been paid more and more attention, however, there is no screening method for multiple myeloma prognosis genes in the world

Method used

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  • A screening method for multiple myeloma prognostic genes
  • A screening method for multiple myeloma prognostic genes
  • A screening method for multiple myeloma prognostic genes

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Embodiment Construction

[0039] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments It is some embodiments of the present invention, but not all of them. Based on the implementation manners in the present invention, all other implementation manners obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention. Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the implementation manners in the present invention, all other implement...

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Abstract

The present invention provides a method for screening multiple myeloma prognosis genes based on a gene co-expression network, comprising the following steps: S1, obtaining the gene expression profile GSE24080 of MM patients from the GEO database, and analyzing the gene expression profile GSE24080 The genes in are preprocessed to obtain the top 25% of the 5413 genes with the largest expression value variance; S2, WGCNA gene co-expression network analysis is performed on the 5413 genes to identify co-expressed functional modules; S3, through Pearson correlation The test evaluates the correlation between the functional modules and clinical information to identify the most significant modules.

Description

technical field [0001] The invention relates to a method for screening multiple myeloma prognosis genes based on a gene co-expression network. Background technique [0002] Multiple myeloma (MM) is a malignant plasma cell disease in which tumor cells originate from plasma cells in the bone marrow, which are cells that develop to the final functional stage of B lymphocytes. At present, the heterogeneity of multiple myeloma has been paid more and more attention. However, there is no screening method for multiple myeloma prognostic genes in the world. Contents of the invention [0003] The present invention provides a screening method for multiple myeloma prognosis genes based on gene co-expression network, which can effectively solve the above problems. [0004] The present invention is achieved like this: [0005] A method for screening multiple myeloma prognosis genes based on a gene co-expression network, characterized in that it comprises the following steps: [0006]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B35/20G16B45/00G16B25/10G16B50/30
CPCG16B35/20G16B45/00G16B25/10G16B50/30
Inventor 曾志勇陈君敏
Owner THE FIRST AFFILIATED HOSPITAL OF FUJIAN MEDICAL UNIV
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