Method for implementing optical coherence tomography guided laser thrombus dissolving in blood vessels

Abstract

The invention provides a method for selectively using 308nm and 2-micron laser to dissolve thrombus under the guidance of optical coherence tomography. The elements involved in the method include optical coherence tomography (OCT) equipment, a 308nm excimer laser, a 2-micron laser an optical catheters; the OCT equipment is used for observing thrombus in blood vessels and selecting different lasersto perform laser thrombus dissolving by judging the composition of the thrombus according to OCT imaging; the 308nm excimer laser is used for generating 308nm laser pulses mainly acting on non-calcified thrombus; the 2-micron laser is used for generating 2-micron laser pulses mainly used for eliminating the calcified thrombus; the optical catheters are connected with the OCT equipment, the 308nmexcimer laser and the 2-micron laser respectively and are composed of an OCT catheter, a 308nm excimer layer catheter and a 2-micron laser catheter which are used for observing the thrombus in the blood vessels and eliminating the thrombus. By the arrangement, simple structure and convenient operation are achieved, and the method has high application value and broad application prospect in the field of laser thrombus dissolving.

Description

[0001] (1) Technical field [0002] The invention relates to a method for selectively utilizing 308nm and 2 micron lasers to perform thrombolysis under the guidance of optical coherence tomography, in particular to the field of laser thrombolysis. [0003] (2) Background technology [0004] Thrombosis is the coagulation of blood in a blood vessel to form a clot that slows or even blocks blood flow. The slowing or stopping of blood flow will affect the nutrient supply of downstream tissues and the exchange of carbon dioxide and oxygen, resulting in tissue ischemia and necrosis, thus endangering life and health. Ischemic stroke, myocardial infarction and venous thromboembolism caused by thrombus are the three major killers of cardiovascular and cerebrovascular diseases. At present, the main methods of thrombolysis include drug method, mechanical thrombolysis, ultrasonic thrombolysis, mechanical thrombolysis and laser thrombolysis. Among them, although the drug method is the ear...

AI Technical Summary

Problems solved by technology

However, the 308nm laser mainly acts on protein and fat, and cannot abolish calcified thrombus well

Compared with 308nm laser, 2 micron laser has stronger shock wave and tissue thermal effect, which can ablate calcified thrombus, but excessive shock wave may cause side effects such as tissue stripping, intramural hemorrhage and even perforation

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