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Method for extracting ellagic acid and chebulic acid from fructus chebulae and composition of the method

An extraction method and ellagic acid technology, which are applied in the field of extraction methods and compositions of ellagic acid and ellagic acid in Myrobalan, can solve the problems of low purity and complicated purification components, and achieve simple component types, Extraction is highly targeted and improves the effect of lowering blood pressure and lipids

Active Publication Date: 2019-07-05
内蒙古阿尔善药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In order to solve the problems of complex purified components and low purity in the prior art, the present invention provides a method for extracting ellagic acid and chebulic acid in chebula, comprising the following steps:

Method used

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  • Method for extracting ellagic acid and chebulic acid from fructus chebulae and composition of the method
  • Method for extracting ellagic acid and chebulic acid from fructus chebulae and composition of the method
  • Method for extracting ellagic acid and chebulic acid from fructus chebulae and composition of the method

Examples

Experimental program
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Effect test

Embodiment 1

[0071] Extraction method of ellagic acid and chebulic acid:

[0072] (1) pretreatment: the chebula is pulverized and crossed 200 mesh sieves;

[0073] (2) Extraction 1: reflux extraction of pulverized chebula, the solvent used for reflux extraction is methanol-ethanol-water solution, wherein methanol:ethanol:water=5:5:1, solvent: chebula=8:1, and then pass Microporous membrane to obtain solid A and extract A; reflux extraction conditions are: reflux temperature is 45°C; reflux time is 1h

[0074] (3) Extraction 2: The solid A is subjected to reflux extraction again, and the solvent used for reflux extraction is acetic acid-water solution, wherein, acetic acid: water = 2: 1, solvent: chebula = 5: 1, and then pass through a microporous membrane to obtain Solid B and extract B; reflux extraction conditions are: reflux temperature is 80°C; reflux time is 1h.

[0075] (4) Separation: Mix extract A and extract B, concentrate, pass through HPD-100 macroporous adsorption resin, mass...

Embodiment 2

[0080] Extraction method of ellagic acid and chebulic acid:

[0081] (1) pretreatment: 300 mesh sieves are pulverized by Myrobalan;

[0082] (2) Extraction 1: reflux extraction of the pulverized chebula, the solvent used for reflux extraction is methanol-ethanol-water solution, wherein methanol:ethanol:water=5:10:1, solvent: chebula=12:1, and then pass Microporous membrane to obtain solid A and extract A; reflux extraction conditions are: reflux temperature is 65°C; reflux time is 3h

[0083] (3) Extraction 2: The solid A is subjected to reflux extraction again, and the solvent used for reflux extraction is acetic acid-water solution, wherein, acetic acid: water = 5: 1, solvent: chebula = 10: 1, and then pass through a microporous membrane to obtain Solid B and extract B; reflux extraction conditions are: reflux temperature is 65°C; reflux time is 3h.

[0084] (4) Separation: Mix extract A and extract B, concentrate, pass through SD-300 macroporous adsorption resin, mass fra...

Embodiment 3

[0089] Extraction method of ellagic acid and chebulic acid:

[0090] (1) pretreatment: 250 mesh sieves are pulverized by Myrobalan;

[0091] (2) Extraction 1: Reflux extraction of pulverized chebula, the solvent used for reflux extraction is methanol-ethanol-water solution, wherein methanol:ethanol:water=5:8:1, solvent: chebula=10:1, and then pass Microporous membrane to obtain solid A and extract A; reflux extraction conditions are: reflux temperature is 50°C; reflux time is 2h

[0092] (3) Extraction 2: The solid A is subjected to reflux extraction again, and the solvent used for reflux extraction is acetic acid-water solution, wherein, acetic acid: water = 3: 1, solvent: chebula = 8: 1, and then pass through a microporous membrane to obtain Solid B and extract B; reflux extraction conditions are: reflux temperature is 70°C; reflux time is 2h.

[0093] (4) Separation: Mix extract A and extract B, concentrate, pass through D-101 macroporous adsorption resin, and elute with ...

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Abstract

The invention relates to the field of traditional Chinese medicine extracts, in particular to a method for extracting ellagic acid and chebulic acid from fructus chebulaeand a composition of the method. The method comprises the following steps: pretreating, crushing and sieving the fructus chebulae; refluxing and extracting the crushed fructus chebulae, and then treating the extract through a microporous filter membrane to obtain a solid A and an extracting solution A; refluxing and extracting the solid A, and treating the extract through a microporous filter membrane to obtain a solid B and an extracting solution B; mixing the extracting solution A with the extracting solution B, concentrating, treating through macroporous adsorption resin, eluting with a solvent, crystallizing and dryingto obtain the ellagic acid and chebulic acid from the fructus chebulae. The extracting method can extract the ellagic acid and the chebulic acid in the fructus chebulae in a targeted manner, and thecontent purity of the ellagic acid and the chebulic acid is high. The invention also provides a product with positive effects on treatment of hypertension and hyperlipidemia, and the product also haseffects of diminishing inflammation and improving eyesight.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extracts, in particular to a method for extracting ellagic acid and chebulic acid from chebula chebula and a composition thereof. Background technique [0002] With the rapid development of the economy, people's dietary structure and habits have undergone relatively large changes, and many people also cause excessive energy intake while gluttonous meals, so the so-called "rich man's disease" represented by high blood pressure and high blood fat "One after another. Hypertension and hyperlipidemia are the source of many diseases. With people's high-fat and high-salt diet and unreasonable eating habits, the human body's metabolism is disordered. High fat can lead to elevated blood lipids, and hyperlipidemia is a risk factor for stroke, coronary heart disease, myocardial infarction, and sudden death. In addition, hyperlipidemia is also an important risk factor for hyperlipidemia, impaired...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K36/744A61P9/12A61P3/06A61P27/02A61P29/00A23F3/34
CPCA61K36/286A61K36/185A61K36/744A61K36/484A61P9/12A61P3/06A61P27/02A61P29/00A23F3/34A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 白吉日木吐李金柱张海玉赖苏雅拉吐
Owner 内蒙古阿尔善药业有限公司
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