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Skin aging-resistant tetrapeptide and use thereof

A technology of anti-skin aging and skin care products, applied in the field of amino acid peptides, can solve skin aging and other problems, achieve the effect of inhibiting elastase activity and reducing fibroblast apoptosis

Active Publication Date: 2019-02-01
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the accumulated damage of ultraviolet rays to the skin is also one of the culprits leading to skin aging, but the above-mentioned patent does not report on the effect of hexapeptide on aging caused by ultraviolet rays

Method used

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  • Skin aging-resistant tetrapeptide and use thereof
  • Skin aging-resistant tetrapeptide and use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] When the concentration of tetrapeptide GLPY was 10mmol / L, its elastase inhibitory activity was 51.18%.

Embodiment 2

[0041] The tetrapeptide GLPY, at a concentration of 200 μmol / L, was used to test the survival rate of fibroblasts under light damage. The results are as follows figure 1 shown.

Embodiment 3

[0046] The effects of tetrapeptide GLPY at a concentration of 200 μmol / L on collagen and elastin in photoaged fibroblasts are as follows: figure 2 shown.

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Abstract

The invention discloses a skin aging-resistant tetrapeptide and a use thereof. The amino acid sequence of the tetrapeptide is Gly-Lue-Pro-Tyr(GLPY), the molecular weight is 449.2393 Da, and the tetrapeptide is synthesized through a chemical synthesis method in the prior art. The tetrapeptide GLPY can bind to elastase in order to inhibit the activity of the elastase and reduce fibroblast apoptosiscaused by photodamage, so the tetrapeptide has skin aging resistance, and can be used for preparing healthcare products and skincare products with an anti-aging effect.

Description

technical field [0001] The invention belongs to the field of amino acid polypeptides, in particular to an anti-aging tetrapeptide GLPY and its application. Background technique [0002] Delaying skin aging and maintaining youth is the eternal dream of people, especially women, for thousands of years. The aging mechanism of skin is complex and is the result of a combination of factors, such as oxidative stress, UV damage, glycosylation, and the breakdown of the balance of the matrix metalloproteinase system. [0003] The characterization of skin aging is also diverse, mainly the destruction of skin structure and function, which is reflected in the degradation of structural proteins (collagen and elastin) and abnormal epidermal structure. The aging of the skin leads to the appearance of a series of problems, such as dryness, wrinkles, sagging, and pigmentation. [0004] With the in-depth research on the mechanism of skin aging, scientists have found that matrix metalloprotei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/103A61Q19/08A61P17/18A61P17/00A61K38/00A61K8/64
CPCA61K8/64A61K38/00A61K2800/782A61P17/00A61P17/18A61Q19/08C07K5/1008
Inventor 赵谋明刘洋苏国万
Owner SOUTH CHINA UNIV OF TECH
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