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Application of epoxydaucenal A and B in hematopoietic stem cell aging resistance

A technology of hematopoietic stem cells and carrots, applied in the field of biomedicine, can solve problems such as decreased hematopoietic function, decreased function and number of hematopoietic stem cells, and immune function decline

Inactive Publication Date: 2019-02-01
北京中申安德森生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the basic components of the hematopoietic system are maintained during the aging process of the body, the function and number of hematopoietic stem cells gradually decrease, which leads to the decline of the body's hematopoietic function and immune function
There is no report on the anti-senescence of these compounds in hematopoietic stem cells

Method used

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  • Application of epoxydaucenal A and B in hematopoietic stem cell aging resistance
  • Application of epoxydaucenal A and B in hematopoietic stem cell aging resistance
  • Application of epoxydaucenal A and B in hematopoietic stem cell aging resistance

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Embodiment Construction

[0016] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0017] 1. Experimental materials

[0018] Healthy and clean C57BL / 6J mice, male and female, 6-8 weeks old, weighing 18-20 g, were provided by the Animal Center of China Pharmaceutical University. Epoxycarotene A, Epoxycarotene B, Rose Acid A, Rose Acid B and Rose Acid D are self-made, with a purity of ≥98%, and are stored dry. Anti-Sca-1 MicroBead Kit was purchased from Miltenyi Company. SA-β-Gal Staining Kit was purchased from Cell Signaling Company. Methylcellulose medium MethoCult GF M3434 was purchased from Stem Cell Company.

[0019] 2. Experimental method

[0020] 1. Preparation of hematopoietic stem cell aging model and group intervention

[0021] C57BL / 6J mice were randomly divided into control group, model group and administration group (including epoxycarotene al...

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Abstract

The invention discloses an application of epoxydaucenal A and B in hematopoietic stem cell aging resistance. Hematopoietic stem cells undergo self-renewal, differentiation, aging, death and other complex processes to maintain the generation of blood cells all one's life; and the maintenance of basic components of the hematopoietic system of a body and the gradual reduction of the functions and thequantity of hematopoietic stem cells in the aging process lead to the hematopoiesis function reduction and the immune function decline of the body. It is found in the invention that the epoxydaucenalA, the epoxydaucenal B, roseolic acid A or roseolic acid D can inhibiting p16 gene transcription in order to resist hematopoietic stem cell aging, and the epoxydaucenal A, the epoxydaucenal B, the roseolic acid A or the roseolic acid D can be processed to prepare a p16 gene transcription inhibitor and a drug for resisting hematopoietic stem cell aging.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to anti-aging of hematopoietic stem cells, in particular to an application of epoxycarotene aldehydes A and B in anti-aging of hematopoietic stem cells. Background technique [0002] Hematopoietic stem cells undergo complex processes such as self-renewal, differentiation, aging and death to maintain the body's lifelong blood cell production. Although the basic components of the hematopoietic system are maintained during the aging process of the body, the function and number of hematopoietic stem cells gradually decrease, which leads to the decline of the body's hematopoietic function and immune function. [0003] At present, aging is considered to be a gene-related disease, and the tumor suppressor gene p16 is a key gene regulating cell aging. Studies have confirmed that when cells are senescent, the transcription and protein expression levels of p16 gene increase, inhibit cell mitosis, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/336A61K31/357A61K31/35A61P39/06
CPCA61K31/336A61K31/35A61K31/357A61P39/06A61K2300/00
Inventor 郑嘉荣区伟平
Owner 北京中申安德森生物科技有限公司
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