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Method for monitoring high-intensity focused ultrasound treatment acoustic cavitation in real time

A focused ultrasound and real-time monitoring technology, applied in ultrasonic therapy, treatment and other directions, can solve the problem that the generation process and evolution of acoustic cavitation bubble groups cannot be accurately represented, and the safety, effectiveness and repeatability of HIFU treatment cannot be guaranteed. It is impossible to realize the problems of voice-controlled monitoring, so as to achieve the effect of improving the monitoring accuracy, good monitoring effect and convenient implementation.

Active Publication Date: 2018-08-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] To sum up, the existing acoustic cavitation monitoring technology during HIFU treatment cannot realize accurate sound-controlled monitoring, and cannot accurately represent the generation process a

Method used

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  • Method for monitoring high-intensity focused ultrasound treatment acoustic cavitation in real time
  • Method for monitoring high-intensity focused ultrasound treatment acoustic cavitation in real time
  • Method for monitoring high-intensity focused ultrasound treatment acoustic cavitation in real time

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Experimental program
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Embodiment 1

[0047] In this embodiment, a method for real-time monitoring of acoustic cavitation in high-intensity focused ultrasound treatment involves performing HIFU treatment on the treatment area set in the HIFU treatment plan. After HIFU treatment, cavitation occurs in this area, and cavitation bubble groups are generated. The cavitation bubble group changes with time, and the B-ultrasound image collector observes the space-time behavior of the cavitation bubble group, collects the image of the cavitation bubble group in real time, and records the video data of the space-time behavior of the cavitation bubble group; refer to figure 1 , including the following steps, firstly carry out HIFU radiation on the phantom in vitro, and use a B-ultrasound image collector to observe and record the spatiotemporal behavior of the cavitation bubble group in the phantom; The video images of the B-ultrasound image are processed, and each frame of B-ultrasound image is processed, and the processing p...

Embodiment 2

[0049] A method for real-time monitoring of high-intensity focused ultrasound treatment of acoustic cavitation in this embodiment is based on Embodiment 1, and the video data of the temporal and spatial behavior of the cavitation bubble group collected by the B-ultrasound image collector is stored in the computer for future reference. The video image of the spatio-temporal behavior of the cavitation bubble group in the computer is followed by off-line image processing; each frame of the video image of the in vitro phantom collected by the B-ultrasound image collector is processed. The processing process includes band-pass filter processing, using FIR The band-pass filter processes each frame of B-ultrasound image and extracts the second harmonic signal. The frequency of the sub-harmonic signal is defined as 1 / 2 of the central operating frequency of the B-ultrasound probe, and the filtering bandwidth of the FIR band-pass filter is set to B 50%-80% of the center operating frequen...

Embodiment 3

[0051] In this embodiment, a method for real-time monitoring of acoustic cavitation in high-intensity focused ultrasound treatment is based on Embodiment 1. HIFU treatment is performed on the treatment area set in the HIFU treatment plan, and acoustic cavitation occurs in this area after HIFU treatment. Generate cavitation bubble groups, according to the treatment area set by the HIFU treatment plan, select the region containing cavitation bubbles in each frame of B-ultrasound image after processing as the region of interest, and select a rectangular region of equal area near the region of interest For the reference area, refer to image 3 , the dark box in the middle is the ROI, the light box on the right is the reference area, and the area of ​​the ROI and the reference area are equal.

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Abstract

The invention discloses a method for monitoring high-intensity focused ultrasound treatment acoustic cavitation in real time and belongs to the technical field of HIFU treatment acoustic cavitation monitoring. An in vitro phantom is subjected to HIFU radiation, a B-mode ultrasound image collector is adopted to observe and record space-time behaviors of a cavitation bubble group in the phantom, video images collected by the B-mode ultrasound image collector about the space-time behaviors of a cavitation bubble group are processed, a region of interest and a reference region are chosen from eachframe of processed B-mode ultrasound image and then compared with each other, a relative p-value reflecting acoustic cavitation intensity of each frame of image is calculated, and the space-time behaviors of the cavitation bubble group can be determined according to the relative p-value corresponding to each frame of B-mode ultrasound image obtained from a fourth step. Via the method, acoustic cavitation generation processes and evolution conditions can be precisely monitored, and high monitoring accuracy and great monitoring effects can be realized; safety, effectiveness and repeatability ofHIFU treatment can be ensured.

Description

technical field [0001] The invention belongs to the technical field of monitoring acoustic cavitation in HIFU treatment, and in particular relates to a method for real-time monitoring of acoustic cavitation in high-intensity focused ultrasound treatment. Background technique [0002] The therapeutic source of High Intensity Focused Ultrasound (HIFU) is ultrasound. Similar to the principle that solar cookers focus sunlight to generate huge energy at the focus, this technology focuses low-energy ultrasound in vitro on the target area in the body, and produces biological effects such as transient high temperature (above 60°C), cavitation, and mechanical action in the tumor. Kill tumor cells in the target area. High Intensity Focused Ultrasound (HIFU) can precisely focus sound energy in a predetermined treatment area in the patient's body without damaging normal tissues and organs around the area. These characteristics make HIFU widely used in the treatment of tumors, hemostas...

Claims

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Application Information

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IPC IPC(8): A61N7/02
CPCA61N7/02A61N2007/0039
Inventor 黄品同
Owner ZHEJIANG UNIV
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