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Colon cancer individuation prognosis evaluation method based on multigene expression characteristic spectrum

A technology of gene expression profiling and expression signature, applied in the field of personalized prognosis assessment of colon cancer

Active Publication Date: 2018-07-24
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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Problems solved by technology

However, most reports only use single or several genes, can only classify a group, and can only qualitatively divide the individual survival period (such as two indicators of good prognosis and poor prognosis)

Method used

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  • Colon cancer individuation prognosis evaluation method based on multigene expression characteristic spectrum
  • Colon cancer individuation prognosis evaluation method based on multigene expression characteristic spectrum
  • Colon cancer individuation prognosis evaluation method based on multigene expression characteristic spectrum

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Embodiment Construction

[0061] The implementation of the present invention will be described in detail below with examples, so as to fully understand and implement the implementation process of how the present invention uses technical means to solve technical problems and achieve technical effects.

[0062] The invention discloses a method for evaluating the individualized prognosis of colon cancer based on a polygene expression profile, comprising the following steps:

[0063] Step 1. Obtain the colon cancer prognosis risk gene list and gene weight, specifically:

[0064] Step 1.1, download the tumor tissue and paracancerous tissue transcriptome data and clinical data of colon cancer patients from the Genomic Data Commons Data Portal database, and obtain the tumor tissue gene expression profile FPKM of colon cancer patients ( F fragments P er K ilobase of transcript per M million fragments mapped) values, logarithmic transformation (log2).

[0065] Step 1.2, set the total number of samples as m,...

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Abstract

The invention discloses a colon cancer individuation prognosis evaluation method based on a multigene expression characteristic spectrum. The method comprises the following steps: obtaining a colon cancer prognosis risk gene list and gene weight; using the tumor tissue transcriptome and survival data of colon cancer patients to construct a prognosis evaluation model; calculating the risk scores ofthe patients according to the gene expression profile of tumor tissues of the colon cancer patients; and calculating the annual survival probability of the patients according to the risk scores of the patients. The annual survival probability of the colon cancer patients obtained by the method disclosed by the invention is highly coincident with actual annual survival probability (linear dependence R2 being equal to 0.988, and P value being 7.35E-39). It is proved that the method has extremely high prediction accuracy, and the result is highly coincident with actual survival condition. Moreover, for each tumor patient, the specific survival probability curve of the patient can be given out.

Description

technical field [0001] The invention belongs to the fields of biotechnology and medicine, and in particular relates to a method for evaluating the individualized prognosis of colon cancer based on a polygene expression profile. Background technique [0002] Colon cancer is a malignant tumor with high incidence in China and the world. Statistics show that colorectal cancer ranks third among male cancer patients and second among female cancer patients worldwide. Global Burden of Disease (GBD) data shows that in 2016, the number of people suffering from colorectal cancer worldwide reached 6.32 million, of which 1.47 million were in China. In 2016, the number of deaths of colorectal cancer patients worldwide was 830,000, accounting for 1.52% of the total deaths. In 2016, the number of patients who died in China exceeded 160,000, accounting for 1.73% of the total number of deaths. Statistics show that from 1990 to 2016, the prevalence and mortality of colorectal cancer continu...

Claims

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Application Information

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IPC IPC(8): G16H50/30G16H50/50
Inventor 李文兴李功华黄京飞赵旭东代绍兴
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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