Compound with propanohydrazide structure and preparation method and application of compound
A compound, the technology of hydrazine hydrate, which is applied in the field of medicine and can solve problems such as limited applications
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0023] The synthesis of embodiment 1 compound I-1
[0024]
[0025] Step 1. Synthesis of Compound VI-1
[0026] Compound II (1.32g, 20mmol) was dissolved in 20mL DMSO, stirred at room temperature, KOH solid (2.24g, 40mmol) was added, and stirred at room temperature for 1 hour. Further MeI (III-1, 2.84 g, 20 mmol) was added, and stirring was continued overnight at room temperature. Then tert-butyl acrylate V-1 (2.56 g, 20 mmol) was added, and the stirring was continued for 12 hours, and TLC detection found that the reaction was complete.
[0027] The reaction mixture was carefully poured into 200mL ice water, stirred, and washed with 50mL×3CH 2 Cl 2 After extraction, the extract phases were combined, washed with 100 mL of 5% brine, and dried over anhydrous sodium sulfate. The desiccant was removed by suction filtration, the filtrate was evaporated to dryness on a rotary evaporator, and the residue was purified by silica gel column chromatography to obtain compound VI-I,...
Embodiment 2
[0034] The synthesis of embodiment 2 compound 1-2
[0035]
[0036] Step 1. Synthesis of compound VI-2
[0037] Compound II (1.32g, 20mmol) was dissolved in 20mL DMSO, stirred at room temperature, KOH solid (2.24g, 40mmol) was added, and stirred at room temperature for 1 hour. Compound III-1 (2.84 g, 20 mmol) was added, and stirring was continued overnight at room temperature. Then 20 mmol of compound V-2 was added, and the stirring was continued for 12 hours, and TLC detection found that the reaction was complete. The reaction mixture was carefully poured into 200mL ice water, stirred, and washed with 50mL×3CH 2 Cl 2 After extraction, the extract phases were combined, washed with 100 mL of 5% brine, and dried over anhydrous sodium sulfate. The desiccant was removed by suction filtration, the filtrate was evaporated to dryness on a rotary evaporator, and the residue was purified by silica gel column chromatography to obtain compound VI-2. ESI-MS, m / z=223 ([M+H] + ). ...
Embodiment 3-6
[0043] Referring to the operation steps of Example 1, the compounds listed in the following table were synthesized.
[0044]
[0045]
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com