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Method for dynamically measuring oxygen extraction fraction (OEF)

A technology of oxygen uptake rate and dynamic measurement, which is applied to measuring devices, measuring magnetic variables, magnetic resonance measurement, etc., can solve the problems that cannot meet the requirements of time resolution, and achieve the effect of saving time and cost

Active Publication Date: 2018-03-30
PEKING UNIV
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Problems solved by technology

Therefore, GESSE imaging technology cannot meet the time resolution requirements of OEF dynamic measurement

Method used

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  • Method for dynamically measuring oxygen extraction fraction (OEF)
  • Method for dynamically measuring oxygen extraction fraction (OEF)
  • Method for dynamically measuring oxygen extraction fraction (OEF)

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Embodiment Construction

[0032] In order to make the features of the present invention more comprehensible, the following uses representative preferred embodiments and explains in detail in conjunction with the accompanying drawings. It should be noted that the present invention is not limited to the described specific structures, functions, devices and methods, and may also have other implementations or combinations of other implementations. The number of elements described in the present invention may also be set in plural. In addition, in order to avoid confusion between other examples and the present invention, some technical features and details well known in the art have not been described.

[0033] The present invention provides a new spin echo-echo planar imaging sequence based on multiple time offsets, which is named MOSE-EPI (Multiple-Offset-Spin-Echo Echo-Planar Imaging). Because of its high time resolution, the sequence can be applied to the study of functional magnetic resonance imaging ...

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Abstract

The invention discloses a method for dynamically measuring an oxygen extraction fraction (OEF), an acquisition mode based on echo planar imaging is adopted, i.e., an acquisition mode of exciting and utilizing an echo chain formed by multi-gradient forward and reverse direction rapid switching once to fill K space in one time, so that time resolution is greatly improved, multi-offset-spin-echo imaging is utilized to measure change of an MR signal in a tissue, and later dynamic measurement of the OEF is realized through a relation between the change and tissue OEF. The method for dynamically measuring the OEF solves the problem of relatively long acquisition time of a traditional scanning sequence GESSE caused by the acquisition mode, the time resolution of OED measurement is greatly improved, and it is hopeful to study physiological change from a new angle of view and promote development of neuroscience and clinical medicine.

Description

technical field [0001] The invention relates to the field of magnetic resonance imaging, in particular to a method for dynamically measuring oxygen uptake rate. Background technique [0002] Oxygen Extraction Fraction (OEF) describes the amount of oxygen taken up by tissues from blood when blood flows through the capillary bed, that is, the ratio of oxygen consumption to oxygen supply. The main energy required for organ activities comes from aerobic metabolism, so OEF can directly reflect the sustainability and activity of organs, and is an important indicator of organ health and function. In terms of clinical application, OEF is used to study diseases related to oxygen consumption, such as cerebral infarction, tumor, senile dementia, cerebral ischemia, and anemia. In terms of cognitive neuroscience, the study of OEF in functional stimulation will help to understand the activity process between related brain regions and specific psychological stages, so the study of OEF dyn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/54G01R33/561G01R33/563
CPCG01R33/543G01R33/561G01R33/5613G01R33/56308
Inventor 高家红殷雅彦
Owner PEKING UNIV
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