Method for making sharp composite particles for improving fracture healing

Abstract

The invention provides a method for making pointed composite particles for improving fracture healing, which includes the following steps: 1) making a model whose apex section is "U"-shaped and consistent with the fracture line section; 2) making wet elastic layer, drug layer, the elastic layer is a dense degradable or non-degradable biofilm, the material of the drug layer is a degradable or non-degradable, absorbable or non-absorbable or porous material that is biocompatible with human bone, and the drug The inside of the layer is also encapsulated with drugs that can promote bone healing; 3) Cover the wet elastic layer on the top corner of the model, wrap the top corner of the model and extend to both sides of the top corner of the model, and then apply the wet drug layer Cover the elastic layer to form a biological microstructure film; 4) Cut the biological microstructure film in the width direction as required; 5) After the composite particles are air-dried and the shape is fixed, peel the prepared composite particles from the top corner of the model .

Description

technical field [0001] The invention relates to a preparation method of pointed composite particles for improving fracture healing. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fracture anastomotic line, an...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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