Phosphorylated schizophyllan derivatives and their preparation methods and applications

Abstract

The invention discloses a phosphorylated derivative of schizophyllan. The phosphorylated derivative of schizophyllan is prepared from, by mass, 1 to 10% of schizophyllan ad 1.5 to 20% of a phosphorylation reagent, with the balance being a solvent. The invention also discloses a preparation method for the phosphorylated derivative of schizophyllan. The preparation method comprises the following steps: (1) adding schizophyllan and the phosphorylation reagent into the solvent and carrying out mixing and a stirring reaction; and (2) subjecting a reaction solution obtained after the reaction in thestep (1) to separation and purification so as to obtain the phosphorylated derivative of schizophyllan. The phosphorylated derivative of schizophyllan has the advantages of good instant and long-lasting effect when used as an antioxidation active component, a humectant and an anti-aging active component for preparation of external agents for skin.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a phosphorylated schizophyllan derivative, a preparation method and application thereof. Background technique [0002] With the improvement of living standards, people pay more and more attention to skin care (especially the care of facial skin). Skin care starts with replenishing skin moisture, because skin dehydration will not only reduce the metabolism and cell vitality of skin cells, resulting in fine lines, wrinkles, dullness, color spots and other problems on the skin, but also keep the skin in a sub-healthy state , leading to poor skin tolerance, easy to be stimulated by the outside world, causing allergies, red blood and other problems; the lack of water in the skin can also easily cause the imbalance of water and oil in the skin, forming a skin texture that is oily on the outside and dry on the inside, prone to acne, which is harmful to people's skin. Life...

AI Technical Summary

Problems solved by technology

Since the molecular weight of Schizophyllan is usually over one million, it is difficult to dissolve completely in water, which greatly limits its application in cosmetics

It has been reported in the literature that schizophyllan was physically and chemically modified by methods such as sonication, carboxymethylation, and sulfation. However, the derivatization reagents are expensive, the yield is low, and side reactions such as degradation occur. It is urgent to develop a new method. A simple and cheap derivatization method of schizophyllan to prepare schizophyllan derivatives with good water solubility and multiple functions such as anti-oxidation and moisturizing, which can be used as anti-oxidation active ingredients, moisturizers and anti-aging active ingredients for external skin preparations

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