Manufacturing method of circular biofilm model array

Abstract

The invention provides a manufacturing method of a circular biofilm model array. The method comprises that follow steps: 1) models which have U-shaped vertex cross sections and are matched with the fracture line cross section are manufactured in advance, the U-shaped models get close to each other to form the array, and bottoms of the adjacent U-shaped models are at an interval of 3-5 mm; 2) a wetelastic layer and medicine layer are manufactured respectively, wherein the elastic layer is a dense degradable or non-degradable biofilm, the medicine layer is made of a porous loose material whichis good in biocompatibility with human bone and is degradable or non-degradable and absorbent or non-absorbent, and a medicine with a bone healing promoting effect is also encapsulated in the medicinelayer; 3) the model array is covered with the wet elastic layer, the wet elastic layer wraps vertexes of the models in the array and extends to the periphery of the model array, the wet medicine layer then covers the elastic layer in the same range, and the biological microstructure film is formed; 4) after the biological microstructure film is air-dried and fixed in shape, the biofilm is cut offalong the edge of the corresponding U-shaped model, and the manufactured single biological microstructure film is stripped from the corresponding model.

Description

technical field [0001] The invention relates to a method for making a circular biofilm model array. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fracture anastomotic line, and prevents the reaction of human...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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