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Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the IFP35 family of proteins

一种活性、疾病的技术，应用在过敏性疾病、肽的制备方法、肽/蛋白质成分等方向，能够解决蛋白质功能机制不清楚等问题

Active Publication Date: 2017-12-01
GUANGZHOU INNO-ENMAI BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the functional mechanisms of these proteins are largely unknown

Method used

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  • Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the IFP35 family of proteins
  • Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the IFP35 family of proteins
  • Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the IFP35 family of proteins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0136] Embodiment 1: Use of truncated IFP35 protein in reagents / products that cause immune response and inflammation or in the preparation of anti-tumor products, wherein the truncated IFP35 is human IFP35 or mouse IFP35, wherein the truncated human IFP35 is the following 1) or 2).

[0137] 1) a protein having residues 136-216 as in SEQ ID NO:2;

[0138] 2) The protein sequence as in 1), wherein 1-10 additional residues are added to the amino or / and carboxyl termini of the sequence, and the sequence homology to the sequence of 1) is at least about 90%.

[0139] wherein said truncated mouse IFP35 is the following 3) or 4):

[0140] A protein having residues 134-216 as in SEQ ID NO:4;

[0141] 4) The protein sequence as in 3), wherein 1-10 additional residues are added to the amino or / and carboxyl termini of the sequence, and the sequence homology to the sequence of 3) is at least about 90%.

Embodiment approach 2

[0142] Embodiment 2: The method of Embodiment 1, wherein the truncated human IFP35 protein is represented by residues 124-220 in SEQ ID NO:2.

Embodiment approach 3

[0143] Embodiment 3: A method for preparing immune response / inflammatory products triggered by IFP35 protein or preparing anti-tumor / cancer products, wherein the IFP35 protein sequence is shown in SEQ ID NO:2 or SEQ ID NO:4.

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Abstract

The present invention provides methods and compositions for treating and / or preventing a disease or disorder associated with abnormally high level of the IFP35 family of proteins, including IFP35 and NMI, methods and compositions for diagnosis, prognosis or treatment monitoring of a disease or disorder associated with abnormally high level of the IFP35 family of proteins, including IFP35 and NMI, and methods and compositions for identifying a modulator of the IFP35 family of proteins, including IFP35 and NMI.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to Chinese Patent No. 201410418773.1 filed on August 22, 2014, the disclosure of which is incorporated herein by reference in its entirety for all purposes. technical field [0003] In some aspects, the present disclosure relates to methods and compositions for treating and / or preventing diseases or disorders associated with abnormal levels and / or activities of the IFP35 family of proteins, including IFP35 and NMI; for diagnosis, prognosis, or therapy Methods and compositions for monitoring diseases or disorders associated with abnormal levels and / or activity of the IFP35 family of proteins; and methods and compositions for identifying modulators of the IFP35 family of proteins. Background technique [0004] Endogenous danger signals are "pathogen-associated molecular patterns" (DAMPs) secreted by cells that are dying or under stress that trigger an inflammatory response. For example,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K39/395A61P37/04A61P29/00A61P35/00A61P37/06A61P31/04C07K14/47C12N15/70C07K1/22C07K1/18C07K1/16
CPCC07K16/18C07K16/24A61K2039/505C07K2317/76C07K14/47A61P29/00A61P31/00A61P31/04A61P35/00A61P35/02A61P37/02A61P37/04A61P37/06A61K39/0011C07K2317/565C07K2317/567C12N15/113C12N2310/11G01N33/68G01N2500/04G01N2500/20
Inventor 刘迎芳梁欢欢沈涓夏侯志楷
Owner GUANGZHOU INNO-ENMAI BIOMEDICAL TECH CO LTD
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