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Iron porphyrin organic framework material peroxidase mimetic and its preparation method and application

An organic framework and peroxidase technology, applied in the direction of chemical reaction of materials, analysis of materials, chemiluminescence/bioluminescence, etc., can solve the problems of expensive preparation, purification and storage, application of restriction enzymes, instability, etc. , to achieve high affinity, easy post-processing, and low detection limit

Inactive Publication Date: 2019-10-01
UNIV OF JINAN
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most natural enzymes are proteins in nature, which have unavoidable shortcomings such as instability, expensive preparation, purification and storage, which limit the practical application of enzymes.

Method used

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  • Iron porphyrin organic framework material peroxidase mimetic and its preparation method and application
  • Iron porphyrin organic framework material peroxidase mimetic and its preparation method and application
  • Iron porphyrin organic framework material peroxidase mimetic and its preparation method and application

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Abstract

The invention discloses a ferriporphyrin organic frame material peroxidase mimic. The erriporphyrin organic frame material is prepared from 1,6,7,12-tetrachloro-3,4,9,10-tetracarboxylic acid dianhydride and 5,10,15,20-tetra(4-aminophenyl) porphyrin iron through a solvothermal technology. The ferriporphyrin organic frame material has excellent peroxidase-like catalysis activity, can rapidly and effectively catalyze 3,3',5,5'-tetramethyl benzidine oxidation for generating a typical blue solution in the presence of hydrogen peroxide, and can be used for detecting low-concentration H2O2, and the absorbance of a catalysis product is linearly related with the concentration, in a concentration range, of the hydrogen peroxide. The linear range of detection H2O2 is 1-200 [mu]M, and the detection limit is 0.14 [mu]M.

Description

technical field The invention relates to an iron porphyrin organic framework material with the characteristic of simulating peroxidase, and belongs to the technical field of functional complexes and bionics. Background technique Endogenous small molecules are produced by a variety of different biochemical reactions in the human body, which can truly reflect the pathological and physiological processes of tissue cell metabolism in the body, and have become a hotspot in the research of disease markers. Has shown excellent practical value. Therefore, detecting endogenous small molecules and revealing their levels and abnormal expression will be of great significance for non-invasive early warning, screening and diagnosis of diseases. due to H 2 o 2 It can affect most of the biochemical reactions in the human body and plays an important role in human health. In recent years, H 2 o 2 detection has attracted a lot of attention. Various quantitative detection H 2 o 2 Vari...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/76G01N21/3577
Inventor 朱沛华宋非非王玉栋王榆成
Owner UNIV OF JINAN
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