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Synergistic compositions for treating microbial infections

A technology of nanoparticles and metal nanoparticles, which is applied in the field of compositions containing spherical and coral-shaped nanoparticles and its preparation, and can solve problems such as non-spherical shape processing

Active Publication Date: 2017-08-29
伊沃克纳米公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While these methods provide good control over size, the resulting non-spherical shapes require further processing before they can be made spherical

Method used

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  • Synergistic compositions for treating microbial infections
  • Synergistic compositions for treating microbial infections
  • Synergistic compositions for treating microbial infections

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] Embodiment 1 (spherical nanoparticles)

[0123] A silver (Ag) target was maintained in a chamber through which triple distilled deionized water was flowed. Silver (Ag) targets were ablated using a master laser with a wavelength of 1064 nm, 80 mJ, with a spot size of 1 mm and a pulse length of 9 nanoseconds. The secondary laser is a continuous 532nm laser at 0.5W power, which enters a diffraction grating that produces three distinct electromagnetic fields in front of the silver (Ag) target. This process yielded silver (Ag) nanospheres with an average diameter of 10 nm, with 99+% of those nanospheres being within ±1 nm of the average diameter.

Embodiment 2

[0124] Embodiment 2 (spherical nanoparticles)

[0125] A silver (Ag) target was maintained in a chamber through which triple distilled deionized water was flowed. Silver (Ag) targets were ablated using a master laser with a wavelength of 1064 nm, 620 mJ, with a spot size of 6 mm and a pulse length of 3.7 nanoseconds. The secondary laser is a continuous 532nm laser at 0.5W power, which enters a diffraction grating that generates five distinct electromagnetic fields in front of the silver (Ag) target. This process yielded silver (Ag) nanospheres with an average diameter of 14 nm, with 99+% of those nanospheres being within ±1 nm of the average diameter.

Embodiment 3

[0126] Embodiment 3 (spherical nanoparticles)

[0127] Silver (Ag) anode wire targets are ablated by high voltage (800V) between the target anode and grounded silver (Ag) cathode. Both were submerged in a chamber through which triple distilled deionized water was flowed. The secondary lasers were continuous 1064nm lasers of 5W power, separated without any diffractive grating optics. This process yielded silver (Ag) nanospheres with an average diameter of 10 nm, with 99+% of those nanospheres being within ±1 nm of the average diameter.

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Abstract

Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.

Description

[0001] background 1. Technical field [0002] Disclosed herein are nanoparticle compositions comprising spherical nanoparticles and substances having nanoparticles of globular, coral-like shape and methods of making such compositions. 2. Background technology [0003] The term "nanoparticle" generally refers to particles having a largest dimension of less than 100 nm. Nanoparticle research is currently a hot area of ​​scientific research due to a wide variety of potential applications in biomedicine, optics and electronics. [0004] Nanoparticles have attracted great scientific attention because they can effectively serve as bridges between bulk materials and atomic or molecular structures. Bulk materials generally have constant physical properties regardless of size, but at the nanoscale, size-dependent properties are often observed. Thus, the properties of a material vary as its size approaches the nanoscale, and as the atomic percentage of the material's surface become...

Claims

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Application Information

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IPC IPC(8): B22F9/00B22F1/054B22F1/065
CPCB23K26/032B23K26/123B23K26/127B23K26/082B23K26/0622A01N59/20A61K9/14C10L2200/0204B23K26/361B23K26/1224B22F2999/00B23K2103/02B23K2103/12B22F9/04A01N59/16A61K33/38C10L1/1208B23K26/40B82Y40/00B82Y30/00B23K2103/08B23K2103/14B23K2103/26B22F1/0553B22F1/054B22F1/065A01N25/12A01N25/34B22F2202/05B22F2202/06B22F2202/11A61K9/16A61K9/1682B23K26/362C10L2200/0209Y10S44/00B82Y5/00B82Y99/00B22F2301/255B22F2304/054B22F2998/10B22F1/07B23K26/122
Inventor 威廉·哈罗德·尼德迈尔
Owner 伊沃克纳米公司
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