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lncRNA gene marker and kit for early diagnosis on primary liver cancer

A gene marker, primary liver cancer technology, applied in the field of gene diagnosis, can solve the problems of low sensitivity and specificity, and achieve the effect of excellent diagnostic performance, high accuracy and sensitivity, and strong specificity

Active Publication Date: 2017-07-21
GUANGDONG CELL BIOTECHNOLOGY CO LTD
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AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the deficiencies of the prior art for early diagnosis of primary liver cancer, and the defects of the existing alpha-fetoprotein method for some patients with primary liver cancer with low sensitivity and specificity, and provide a method for early diagnosis of primary liver cancer. Liver cancer lncRNA gene markers for the preparation of kits for early diagnosis of primary liver cancer

Method used

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  • lncRNA gene marker and kit for early diagnosis on primary liver cancer
  • lncRNA gene marker and kit for early diagnosis on primary liver cancer
  • lncRNA gene marker and kit for early diagnosis on primary liver cancer

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Embodiment Construction

[0018] The substantive content of the present invention will be specifically introduced below in conjunction with the embodiments. Due to space reasons, the description of the experimental process cannot be done in great detail. All the parts not described in detail in the experiment are routine operations well known to those skilled in the art.

[0019] 1. Experimental samples

[0020] 1. Test set sample

[0021] The 122 patients with various types of liver diseases were all outpatients or inpatients in Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine from March 2014 to March 2015, including 78 cases in the primary liver cancer group (PHC group) and 44 cases in the benign liver disease group (cirrhosis). 14 cases, 12 cases of acute hepatitis, 12 cases of chronic hepatitis, 6 cases of fatty liver), primary liver cancer patients were confirmed by pathology or imaging. The healthy control group consisted of 36 cases, including 20 males and 16 f...

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Abstract

The invention discloses an lncRNA gene marker and a kit for early diagnosis on primary liver cancer. The lncRNA gene marker consists of an lncRNA MEG3 and lncRNA PRNCR1. When being used for cooperatively diagnosing primary liver cancer and non-primary liver cancer (including benign liver diseases and health control), the plasma lncRNA MEG3 and lncRNA PRNCR1 of the gene marker are excellent in diagnosis performance, high in accuracy and sensitivity and good in specificity, and can be developed into a diagnosis kit for early diagnosis on the primary liver cancer.

Description

technical field [0001] The invention belongs to the field of gene diagnosis, in particular to lncRNA gene markers for early diagnosis of primary liver cancer. Background technique [0002] Primary liver cancer (primay hepatic cancer, PHC) is one of the most common malignant tumors in my country, its mortality rate ranks third among digestive system malignancies, and its incidence rate ranks fifth in the world. [0003] Primary liver cancer is a highly invasive malignant tumor, and the early symptoms are not obvious, so most patients seek treatment late. The main symptoms in the middle and late stages are right upper quadrant pain, epigastric fullness, fever, fatigue, and weight loss. In the late stage, ascites and jaundice are common. It is often at an advanced stage when it is diagnosed, and only 10%-30% of patients can receive radical resection, resulting in poor overall prognosis, and the average survival time is only about 3 months. Most of these patients are the bread...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 王莉张艳峰孙天娇
Owner GUANGDONG CELL BIOTECHNOLOGY CO LTD
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